Роль адипокинов в регуляции функции сердечно-сосудистой системы
https://doi.org/10.18705/1607-419X-2019-25-5-448-459
Аннотация
Жировая ткань является эндокринным органом, секретирующим сигнальные пептиды адипокины. Адипокины играют заметную роль в регуляции иммунной, эндокринной, нервной, выделительной систем организма. Дисбаланс адипокинов приводит к развитию хронического воспалительного состояния, метаболических и сердечно-сосудистых заболеваний. Ожирение как первопричина дисбаланса адипокинов является важнейшим фактором риска возникновения гипертензии, атеросклероза и инфаркта миокарда. Это обусловливает важность экспериментальных и клинических исследований биологии адипокинов для определения перспективных направлений в терапии сердечно-сосудистых заболеваний. Настоящий обзор сфокусирован на рассмотрении роли адипонектина, лептина, хемерина, оментина и висфатина в физиологических и патофизиологических процессах в сердечно-сосудистой системе.
При поддержке: Работа была выполнена при поддержке Гранта Президента Российской Федерации по государственной поддержке ведущих научных школ Российской Федерации НШ-5508.2018.7 (соглашение № 075-152019-161 от 23.05.2019)
Об авторах
А. В. Карпушев
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации
Россия
Россия
Карпушев Алексей Валерьевич — старший научный сотрудник.
Ул. Аккуратова, д. 2, Санкт-Петербург, 197341
SPIN-код: 1379-1339
В. Б. Михайлова
Федеральное государственное бюджетное учреждение Санкт-Петербургский государственный университет
Россия
Россия
Михайлова Валерия Борисовна — студентка 2-го курса магистратуры.
Санкт-Петербург
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Рецензия
Для цитирования:
Карпушев А.В., Михайлова В.Б. Роль адипокинов в регуляции функции сердечно-сосудистой системы. Артериальная гипертензия. 2019;25(5):448-459. https://doi.org/10.18705/1607-419X-2019-25-5-448-459
For citation:
Karpushev A.V., Mikhailova V.B. The role of adipokines in the regulation of cardiovascular function. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2019;25(5):448-459. (In Russ.) https://doi.org/10.18705/1607-419X-2019-25-5-448-459
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