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Артериальная гипертензия

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Роль адипокинов в регуляции функции сердечно-сосудистой системы

https://doi.org/10.18705/1607-419X-2019-25-5-448-459

Полный текст:

Аннотация

Жировая ткань является эндокринным органом, секретирующим сигнальные пептиды адипокины. Адипокины играют заметную роль в регуляции иммунной, эндокринной, нервной, выделительной систем организма. Дисбаланс адипокинов приводит к развитию хронического воспалительного состояния, метаболических и сердечно-сосудистых заболеваний. Ожирение как первопричина дисбаланса адипокинов является важнейшим фактором риска возникновения гипертензии, атеросклероза и инфаркта миокарда. Это обусловливает важность экспериментальных и клинических исследований биологии адипокинов для определения перспективных направлений в терапии сердечно-сосудистых заболеваний. Настоящий обзор сфокусирован на рассмотрении роли адипонектина, лептина, хемерина, оментина и висфатина в физиологических и патофизиологических процессах в сердечно-сосудистой системе.

Об авторах

А. В. Карпушев
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации
Россия

Карпушев Алексей Валерьевич — старший научный сотрудник.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

SPIN-код: 1379-1339



В. Б. Михайлова
Федеральное государственное бюджетное учреждение Санкт-Петербургский государственный университет
Россия

Михайлова Валерия Борисовна — студентка 2-го курса магистратуры.

Санкт-Петербург



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Для цитирования:


Карпушев А.В., Михайлова В.Б. Роль адипокинов в регуляции функции сердечно-сосудистой системы. Артериальная гипертензия. 2019;25(5):448-459. https://doi.org/10.18705/1607-419X-2019-25-5-448-459

For citation:


Karpushev A.V., Mikhailova V.B. The role of adipokines in the regulation of cardiovascular function. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2019;25(5):448-459. (In Russ.) https://doi.org/10.18705/1607-419X-2019-25-5-448-459

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