Cardiospecific autoantibodies in people with vibration disease and type 2 diabetes mellitus
https://doi.org/10.18705/1607-419X-2020-26-5-564-572
Abstract
Background. Metabolic syndrome and diabetes mellitus (DM), as well as a number of environmental factors increase the risk of cardiovascular diseases, which are the leading causes of mortality among working population. Objective. To assess the levels of specific autoantibodies in individuals with vibration disease and type 2 DM. Design and methods. People with vibration disease (group I), patients with type 2 DM (group II), and patients with vibration disease and type 2 DM (group III) were examined. The serum level content of autoantibodies related to vascular state was studied using enzyme immunoassay. Results. More than a quarter of all examined patients had elevated levels of antibodies to the РАРР-А. The changes in the serum level of cardiospecific autoantibodies indicate endothelial damage, alterations of thrombus formation and vascular inflammation. People with vibration disease showed increased incidence of hypoimmunoreactivity of antibodies to collagen, nitric oxide synthase, platelet membrane components, neutrophil and endotheliocyte cytoplasm. Patients with DM had the highest levels of autoantibodies to collagen, nitric oxide synthase, and platelet membrane components. In these patients, increased level of specific autoantibodies to nitric oxide synthase and collagen were found more common. Patients with comorbid pathology showed similar changes: higher rate of reduced level of antibodies to platelet membrane components, nitric oxide synthase and increased level of autoantibodies to nitric oxide synthase and collagen.
About the Authors
L. B. Masnavieva
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
Lyudmila B. Masnavieva, Senior Researcher, Laboratory of Immunobiochemical and Molecular-genetic Studies
3 Mikrorayon 12а, Angarsk, 665827
Phone: 8(3955)55–96–63
I. V. Kudaeva
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
Irina V. Kudaeva, Deputy Director for Research
Angarsk
O. V. Naumova
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
Olga V. Naumova, Junior Researcher, Laboratory of Immunobiochemical and Molecular-genetic Studies
Angarsk
N. P. Chistova
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
Nadezhda P. Chistova, PhD Student
Angarsk
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Review
For citations:
Masnavieva L.B., Kudaeva I.V., Naumova O.V., Chistova N.P. Cardiospecific autoantibodies in people with vibration disease and type 2 diabetes mellitus. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2020;26(5):564-572. (In Russ.) https://doi.org/10.18705/1607-419X-2020-26-5-564-572
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