Structural and functional changes of cardiovascular system in primary hypothyroidism co-existent with hypertension
https://doi.org/10.18705/1607-419X-2015-21-4-403-408
Abstract
Objective. To analyze relationship between thyroid status and target organ damage system in patients with arterial hypertension in combination with primary hypothyroidism (subclinical and compensated).
Design and methods. We enrolled 42 women with primary hypothyroidism and concomitant hypertension aged from 50 to 75 years old. Patients were divided into two comparable groups, the first group included 24 hypertensive patients with subclinical hypothyroidism, the second group included 18 hypertensive patients with compensated hypothyroidism. All patients underwent echocardiography and assessment of endothelial function. Lipids were measured in all patients.
Results. Target organ damage, including left ventricular hypertrophy, left ventricular diastolic dysfunction, and endothelial dysfunction were comparable in both groups. The associations between thyrotrophic hormone and the levels of cholesterol and triglycerides were also similarin both groups.
Conclusions. Subclinical hypothyroidism is neither associated with worsening of hypertension-related target organ damage, nor affects significantly lipid profile.
About the Author
A. V. Nikolaeva
State Budget Educational Institution of Higher Vocational Education “Izhevsk State Medical Academy” of Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
MD, PhD, Professor Assistant, Department of Internal Diseases in Outpatient Setting with the Courses of Clinical Pharmacology and Preventive Medicine,
281, Kommunarov street, Izhevsk, 426034
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Review
For citations:
Nikolaeva A.V. Structural and functional changes of cardiovascular system in primary hypothyroidism co-existent with hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(4):403-408. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-4-403-408
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