Subclinical hypothyroidism and hypertension risk in patients with coronary artery disease
https://doi.org/10.18705/1607-419X-2015-21-4-409-415
Abstract
Background. Thyroid hormones regulate vascular contractility and relaxation. Subclinical hypothyroidism (SH) can cause arterial stiffness and an increase in peripheral vessel resistance. It can lead to atherogenic dyslipidemia, hyperhomocysteinemia and potentiate atherogenesis in coronary artery disease (CAD) and hypertension (HTN).
Objective. To study thyroid function in CAD and HTN, as well as its role in atherogenesis and to specify indications for screening.
Design and methods. We examined 870 CAD patients, who underwent coronarography. Height, weight and body mass index (BMI) were assessed in all participants. The HTN degree was evaluated based on history data. Lipid profile and homocysteine level were assessed before coronarography. Thyroid-stimulating hormone (TSH) level was measured by reagents of 3 generation in order to evaluate thyroid function.
Results. Seventy percent of enrolled patients were overweight or obese. Obesity rate was 2-times higherin women than in men. Obese patients more often had HTN 2–3 degree (32,5%), than patients with normal BMI (14,3%). SH was diagnosed in 12,1%. There was a positive correlation between BMI and TSH in all groups. SH was associated with atherogenic dyslipidemia, hyperhomocysteinemia, and multiple coronary lesions. SH patients had higher risk of HTN. Conclusions. TSH level should be assessed in all patients at cardiovascular risk.
About the Authors
A. R. Volkova
First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
MD, PhD, Associate Professor, IDepartment of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang,
6/8 L. Tolstoy street, St Petersburg, 197022
O. A. Berkovich
First Pavlov State Medical University of St. Petersburg
Russian Federation
MD, PhD, DSc, Professor, Department of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang
Russian Federation
MD, PhD, DSc, Professor, Department of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang
S. V. Dora
First Pavlov State Medical University of St. Petersburg
Russian Federation
MD, PhD, Assistant, IDepartment of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang
Russian Federation
MD, PhD, Assistant, IDepartment of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang
O. D. Dygun
First Pavlov State Medical University of St. Petersburg
Russian Federation
MD, Resident, Department of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang
Russian Federation
MD, Resident, Department of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang
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Review
For citations:
Volkova A.R., Berkovich O.A., Dora S.V., Dygun O.D. Subclinical hypothyroidism and hypertension risk in patients with coronary artery disease. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(4):409-415. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-4-409-415
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