Some markers of endothelial dysfunction in patients with chronic prostatitis
https://doi.org/10.18705/1607-419X-2015-21-4-436-443
Abstract
Objective. To study some markers of endothelial dysfunction depending on the type of autonomic system activity in patients with chronic prostatitis.
Design and methods. Altogether 183 patients with chronic prostatitis were enrolled. The following parameters of endothelial function were assessed: endotheliocyte count, nitrate and nitrite content, concentration of von Willebrand factor.
Results. Autonomic imbalance was found, and increased sympathetic activity (sympathotony) was verified in 70% cases. The level of nitrates and nitrites is decreased, while the concentrations of von Willebrand factor, endothelin and homocystein were increased. Reactive hyperemia test showed lower brachial artery dilation in patients with increased sympathetic activity, as well as the decreased sensitivity of brachial artery to the shear stress.
Conclusion. Endothelial dysfunction is characterized by the increased level of von Willebrand factor, endothelin and homocystein in patients with chronic prostatitis. The activation of sympathetic nervous system plays the key role in the pathogenesis of endothelial dysfunction in patients with chronic prostatitis.
About the Authors
D. N. Zaitsev
Chita State Medical Academy
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Department of Internal Diseases,
39a Gorkogo street, Chita, 672090
A. V. Govorin
Chita State Medical Academy
Russian Federation
MD, PhD, DSc, Head, Department of Internal Diseases
Russian Federation
MD, PhD, DSc, Head, Department of Internal Diseases
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Review
For citations:
Zaitsev D.N., Govorin A.V. Some markers of endothelial dysfunction in patients with chronic prostatitis. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(4):436-443. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-4-436-443
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