Morphological and functional characteristics of tubulointerstitium in IgA-nephropathy
https://doi.org/10.18705/1607-419X-2015-21-5-514-521
Abstract
Objective. The aim of this study was to investigate the vessels and stroma in renal tubulointerstitium in IgAnephropathy.
Design and methods. The coefficient of arterial obstruction was assessed. The laboratory and pathological studies (including immunohistochemistry CD31 and quantitative/semi-quantitative assessment of pathohistopathological changes: atrophy of tubules, local sclerosis, perivascular sclerosis, sclerosed glomeruli, the coefficient of obstruction of the arteries with a diameter greater than 100 microns) were performed.
Results. The serum creatinine level inversely correlated with the obstruction coefficient (r = –0,83, p < 0,05), and positively— with perivascular sclerosis (r = 0,64, p < 0,05). There was a statistically significant positive correlation between CD31+ and creatinine (r = 0,60, p < 0,05), and between CD31+ and arterial obstruction coefficient (r = –0,75, p < 0,05).
Conclusion. The results suggest that the changes in the vascular structure, and therefore the hemodynamic in renal parenchyma may be responsible for fibrosis in the tubulointerstisium in IgA-nephropathy.
About the Authors
V. G. Sipovskiy
First Pavlov State Medical University of St. Petersburg;
V.A. Almazov Federal North-West Medical Research Centre
Russian Federation
Russian Federation
MD, Head, Laboratory of Clinical Immunology and Morphology, Research Institute of Nephrology, 17 L. Tolstoy street, St Petersburg, 197000;
Senior Researcher, Department of Pathology, St Petersburg
R. V. Zverkov
First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
MD, Junior Researcher, Laboratory of Clinical Immunology and Morphology,
17 L. Tolstoy street, St Petersburg, 197000
A. V. Smirnov
First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Director, Research Institute of Nephrology,
17 L. Tolstoy street, St Petersburg, 197000
References
1. Ibels LS, Gyory AZ. IgA-nephropathy: analysis of the natural history, important factorsin the progression of renal disease and a review of the literature. Medicine (Baltimore). 1994;73 (5):79–102.
2. Сиповский В. Г., Добронравов В. А., Корунная А.В., Смирнов А.В. Клинико-морфологический анализ изменений перитубулярных микрососудов интерстиция почек у больных с IgA-нефропатией (IgAN) с оценкой активности лектинового пути системы комплемента. Нефрология. 2013;17(4):32–35. [Sipovskiy VG, Dobronravov VA, Corunaya AV, Smirnov AV. Clinico-morphological analysis of changes in renal interstitial peritubular microvessels in patients with IgA-nephropathy (IgAN) with the assessment the activity of lectin complement system. Nephrology. 2013;17(4):32–35. In Russian].
3. Bohle A, Strutz F, Müller GA. On the pathogenesis of chronic renal failure in primary glomerulopathies: a view from the interstitium. Exp Nephrol. 1994;2(4):205–210.
4. Bohle A, Wehrmann M, Mackensen-Haen S, Gise H, Mickeler E, Xiao TC et al. Pathogenesis of chronic renal failure in primary glomerulopathies. Nephrol Dial Transplant. 1994;9 (3):4–12.
5. Fine LG, Norman JT. Chronic hypoxia as mechanism of progression of chronic kidney disease: from hypothesis to novel therapeutics. Kidney Intern. 2008;74(7):867–872.
6. Семенов Д.В., Смирнов А.В., Кириллова Е.В., Дерябина О.А., Рябиков М.А., Добронравов В.А. Доплерографическая оценка артериального кровотока и изменение функции почек у больных атеросклерозом почечных артерий после реваскуляризации. Нефрология. 2012;16(1):45–52. [Semenov DV, Smirnov AV, Kirillov EV, Deryabina OA, Ryabikov MA, Dobronravov VA. Doplerography assessment of arterial blood flow and changes in renal function in patients with atherosclerosis after renal artery revascularization. Nephrology. 2012;16(1):45–52. In Russian].
7. Шорманов И.С. Морфологические основы нарушения функции почек при расстройстве ренальной гемодинамики. Нефрология. 2005;10(1):62–66. [Shormanov IS. Morphological bases of renal dysfunction in the disorder of renal hemodynamics. Nephrology. 2005;10(1):62–66. In Russian].
8. Хомерики С.Г., Жуков А.Г. Морфологические особенности капиллярной сети слизистой оболочки желудка у больных с портальной гипертензией. Архив патологии. 2011;73 (1):43–46. [Homeriki SG, Zhukov AG. The morphological features of the capillary network of the gastric mucosa in patients with portal hypertension. Arkhiv Patologii = Archives of Pathology. 2011;73 (1):43–46. In Russian].
9. Орлова С. А., Клемина И.К., Никогосян Ю. А., Каюков И.Г. IgA-нефропатия: клинико-морфологические параллели. Нефрология. 2002;6(4):34–33. [Orlova SA, Klemina IK, Nikoghosian YA, Kayukov IG. IgA nephropathy: clinical and morphological parallels. Nephrology. 2002;6(4):34–33. In Russian].
10. Glassock RJ. The pathogenesis of IgA-nephropathy. Curr Opin Nephrol Hypertens. 2011;20(2):153–160.
11. El Karoui K, Hill GS, Karras A, Jacquot C, Moulonguet L, Kourilsky O. et al. Clinicopathologic study of thrombotic microangiopathy in IgA-nephropathy. J Am Soc Nephrol. 2012;23 (1):137–148.
12. Сиповский В.Г., Титова В.А., Пирожков И.А., Лебедев К.И., Смирнов А.В. Анализ стромально-сосудистых маркеров тубулоинтерстиция у больных с IgA-нефропатией. Регионарное кровообращение и микроциркуляция. 2014;13(4):58–66. [Sipovskiy VG, Titova VA, Pirojkoff IA, Lebedev KI, Smirnov AV. Analysis of stromal-vascular markers tubulointerstitium in patients with IgA-nephropathy. Regional Circulation and Microcirculation. 2014;13(4):58–66. In Russian].
13. Sheng-Nan P, Zeng HH, Fu AX, Chen XW, Zhu QX. Protection of rhein on IgA-nephropathy mediated by inhibition of fibronectin expression in rats. Indian J Pharmacol. 2013;45 (2):174–179.
14. Батюшин М.М., Пасечник Д.Г. Выявление виментина, панцитокератина, Е‑катгерина и антител к CD10 маркеров эпителиально-мезенхимального перехода при хроническом гломерулонефрите. Нефрология. 2014;17 (5):23–28. [Batushin MM, Pasechnik DW. Identification of vimentin, pantcytokeratin, е‑Katherin and antibodies to CD10 markers of epithelial-mesenchymal transition in chronic glomerulonephritis. Nephrology. 2014;17(5):23–28. In Russian].
Review
For citations:
Sipovskiy V.G., Zverkov R.V., Smirnov A.V. Morphological and functional characteristics of tubulointerstitium in IgA-nephropathy. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(5):514-521. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-5-514-521
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