Vitamin D level in pregnant women with preeclampsia
https://doi.org/10.18705/1607-419X-2015-21-6-623-629
Abstract
Objective. The objective of this research was to estimate frequency of vitamin D deficiency and insufficiency in pregnant women with preeclampsia.
Design and methods. This is a cohort retrospective and prospective study. From September 2013 to June 2014 we enrolled 99 pregnant women (mean age 29 ± 2,1 years) with preeclampsia (main group, n = 48) and with physiological pregnancy (control group, n = 51). Blood samples were taken from all women for 25 (ОН)D detection. All patients were citizens of St Petersburg and Leningrad region. All of them took multivitamin complex containing vitamin D 400 IU.
Results. Vitamin D deficiency was found in 73 % of women in the main group, while there was not a single case of vitamin D deficiency among controls. The occurrence of vitamin D insufficiency was 25 % and 14 % in the main and control groups, respectively. Only 2 % of women in the main group had normal level of vitamin D, while the rate of normal vitamin D level achieved 86 % in the control group (p < 0,0001).
Conclusions. The frequency of serum vitamin D insufficiency (less than 30 ng/ml) is 2,5‑fold higher in pregnant women with preeclampsia than in control women. The role of vitamin D level (insufficiency and deficiency) as a risk factor for preeclampsia development should be considered in pregnancy.
About the Authors
E. S. Shelepova
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, Researcher, Department of Reproduction and Women Health, Institute of Perinatology and Pediatrics, V. A. Almazov
Federal North-West Medical Research Centre
2 Akkuratov street, St Petersburg, 197341 Russia
N. Yu. Yakovleva
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, Assistant, Department of Obstetrics and Gynecology, V. A. Almazov Federal North-West Medical Research Centre
N. R. Ryabokon’
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, Researcher, Department of Physiology and Pathology of Pregnancy and Delivery, V. A. Almazov Federal North-West
Medical Research Centre
L. V. Kuznetsova
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
PhD, Chief, Department of Reproduction and Women Health, V. A. Almazov Federal North-West Medical Research Centre
E. D. Khadzhieva
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Department of Obstetrics and Gynecology, V. A. Almazov Federal North-West Medical Research Centre
I. E. Zazerskaya
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, DSc, Head, Department of Obstetrics and Gynecology, V. A. Almazov Federal North-West Medical Research Centre
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Review
For citations:
Shelepova E.S., Yakovleva N.Yu., Ryabokon’ N.R., Kuznetsova L.V., Khadzhieva E.D., Zazerskaya I.E. Vitamin D level in pregnant women with preeclampsia. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(6):623-629. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-6-623-629
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