Gender-specific regulation of blood pressure and antihypertensive treatment
https://doi.org/10.18705/1607-419X-2018-24-3-303-308
Abstract
The epidemiology, pathophysiology, clinical manifestations, treatment effects and outcomes of the majority of cardiovascular disease differ between men and women. These differences occur due to the various expression of sex chromosome genes resulting in the different levels of sex hormones. As a result, gender-related differencesin the functioning of cardiovascular system are well-known, including vascular regulation, heart remodeling, drug metabolism, etc. Gender differences related to the cultural and social factors (behaviour, nutrition, life style, coping-strategies, relation to the disease and its prevention, etc.) also affect the course of cardiovascular diseases including hypertension. The gender–related issues of the regulation of blood pressure and therapeutic approaches to the treatment of hypertension remain the subject of high interest and debate.
About the Authors
Kh. I. Ibragimova
Dagestan State Medical University
Russian Federation
Russian Federation
MD, Postgraduate Student, Department of Therapy № 1,
1 Lenin square, Makhachkala, Dagestan, 367012
S. N. Mammaev
Dagestan State Medical University
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Head, Department of Hospital Therapy № 1,
1 Lenin square, Makhachkala, Dagestan, 367012
J. A. Omarova
Dagestan State Medical University
MD, PhD, Associate Professor, Department of Therapy № 1,
1 Lenin square, Makhachkala, Dagestan, 367012
References
1. Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ et al. Heart disease and stroke statistics 2016 update: a report from the American Heart Association. Circulation. 2016;133(4):38–360.
2. Anstey ЕD, Li S, Thomas L, Wang TY, Wiviott SD. Race and sex differences in management and outcomes of patients after ST-elevation and non-ST-elevation myocardial infarct: Results from the NCDR. Clin Cardiol. 2016;39(10):585–595.
3. Potočnjak I, Bodrožić-Džakić T, Šmit I, Trbušić M, Milošević M, Degoricija V. Gender-associated differences in acute heart failure patients presenting to emergency department. Acta Clin Croat. 2015;54(3):257–2565.
4. KesVB, Jurašić MJ, ZavoreoI, Lisak M, JelecV, Matovina LZ. Age and gender differences in acute stroke hospital patients. Acta Clin Croat. 2016;55(1):69–78.
5. Di Pilla M, Bruno RM, Taddei S, Virdis A. Gender differences in the relationships between psychosocial factors and hypertension. Maturitas. 2016;2(16):30135–30139.
6. Сметник В.П. Защитное влияние эстрогенов на сердечнососудистую систему. Консилиум медикум. 2002; Экстравыпуск: 3–6. [Smetnik VP. Protective effect of estrogens on the cardiovascular system. Сonsilium Medicum. 2002; Extra edition: 3–6. In Russian].
7. Юренева С.В., Мычка И.Б., Ильина Л.М., Толстов С.Н. Особенности факторов риска сердечно-сосудистых заболеваний уженщин и роль половых гормонов. Кардиоваскулярная терапия и профилактика. 2011;4:128–135. [Yureneva SV, Ichka IB, Ilina LM, Tolstov SN. Features of risk factors for cardiovascular disease in women and the role of sex hormones. Cardiovascular Therapy and Prevention. 2011;4:128–135. In Russian].
8. Беленков Ю.Н., Фомин И.В., Бадин Ю.В. Гендерные различия в распространенности и эффективности лечения артериальной гипертензии в Европейской части Российской Федерации: результаты исследования ЭПОХА 2007. Проблемы женского здоровья. 2011;4(6):5–11. [Belenkov YuN, Fomin IV, Badin YuV. Gender differences in the prevalence and effectiveness of treatment of hypertension in the European part of the Russian Federation: results of the study EPOCHA 2007. Problems of Women’s Health. 2011;4(6):5–11. In Russian].
9. Оганов Р.Г., Масленникова Г.Я. Гендерные различия кардиоваскулярной патологии. Кардиоваскулярная терапия и профилактика. 2012;11(4):101–104. [Oganov RG, Maslennikova GYa. Gender differences in cardiovascular pathology. Cardiovascular Therapy and Prevention. 2012;11(4):101–104. In Russian].
10. Оганов Р.Г., Тимофеева Т.Н., Колтунов И.Е., Константинов В.В., Баланова Ю.А., Капустина А.В. и др. Эпидемиология артериальной гипертонии в России. Результаты федерального мониторинга 2003–2010 гг. Кардиоваскулярная терапия и профилактика 2011;1(10):9–13. [Oganov RG, Timofeeva TN, Koltunov IE, Konstantinov VV, Balanova YuA, Kapustina AV et al. Epidemiology of arterial hypertension in Russia. The results of the federal monitoring of 2003–2010. Cardiovascular Therapy and Prevention. 2011;1(10): 9–13. In Russian].
11. Nwankwo T, Yoon SS, Burt V, Gu Q. Hypertension among adultsin the United States: National Health and Nutrition Examination Survey, 2011–2012. NCHS Data Brief. 2013;133:1–8.
12. National Center for Health Statistics. Health, United States, 2011. Hyattsville, MD: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics; 2012. URL: https://www.cdc.gov/nchs/data/hus/hus11.pdf
13. Boggia J, Thijs L, Hansen TW, Li Y, Kikuya M, BjörklundBodegård K et al. Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women. Hypertension. 2011;57 (3):397–405.
14. Reckelhoff JF. Basic research into the mechanisms responsible for postmenopausal hypertension. Int J Clin Pract. 2004;(139):3–19.
15. Fortepiani LA, Zhang H, Racusen L, Roberts LJ, Reckelhoff JF. Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats. Hypertension. 2003;41(3 Pt 2):640–645.
16. Pechère-Bertschi A, Burnier M. Female sex hormones, salt, and blood pressure regulation. Am J Hypertens. 2004;17 (10):994–1001.
17. Sharula1, Chekir C, Emi Y, Arai F, Kikuchi Y, Sasaki A et al. Altered arterial stiffness in male-to-female transsexuals undergoing hormonal treatment. J Obstet Gynaecol Res. 2012;38 (6):932–940.
18. Patrizio M, Marano G. Gender differences in cardiac hypertrophic remodeling. Ann Ist Super Sanita. 2016;52(2):223– 229.
19. Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(5):1545–1588.
20. Turnbull F, Woodward M, Neal B, Barzi F, Ninomiya T, Chalmers J et al. Blood pressure lowering treatment trialists’ collaboration. Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. Eur Heart J. 2008;29(21):2669– 2680. doi:10.1093/eurheartj/ehn427
21. Lloyd-Jones DM, Evans JC, Levy D. Hypertension in adults across the age spectrum: current outcomes and control in the community. J Am Med Assoc. 2005;294(4):466–472.
22. Gu Q, Burt VL, Paulose-Ram R, Dillon CF. Gender differences in hypertension treatment, drug utilization patterns, and blood pressure control among US adults with hypertension: data from the National Health and Nutrition Examination Survey 1999–2004. Am J Hypertens. 2008;21(7):789–798.
23. Ong KL, Tso AW, Lam KS, Cheung BM. Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension. 2008;51(4):1142–1148.
24. He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure. Cochrane Database Syst Rev. 2013;(4):CD004937.
25. Rodenburg EM, Stricker BH, Visser LE. Sex-related differencesin hospital admissions attributed to adverse drug reactionsin the Netherlands. Br J Clin Pharmacol. 2011;71(1):95–104.
26. Aronow WS, Fleg JL, Pepine CJ, Artinian NT, Bakris G, Brown AS et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents [published corrections appear in Circulation. 2011;123: e616 and Circulation. 2011;124: e175]. Circulation. 2011;123 (21):2434–2506.
27. Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Mbewu A, Opie LH. Beta-blockers for hypertension. Cochrane Database Syst Rev. 2012;11:CD002003.
28. Engberding N, Wenger NK. Management of hypertension in women. Hypertens Res. 2012;35(3):251–260.
29. Heida KY, Bots ML, de Groot CJ, van Dunné FM, Hammoud NM, Hoek A et al. Cardiovascular risk management after reproductive and pregnancy-related disorders: a Dutch multidisciplinary evidence-based guideline. Eur J Prev Cardiol. 2016;23(17):1863–1879.
30. Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM. Effectiveness-based guidelines for the prevention of cardiovascular disease in women 2011 update. A guideline from the America Heart Association. Circulation. 2011;123(11):1243– 1262.
Review
For citations:
Ibragimova Kh.I., Mammaev S.N., Omarova J.A. Gender-specific regulation of blood pressure and antihypertensive treatment. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2018;24(3):303-308. (In Russ.) https://doi.org/10.18705/1607-419X-2018-24-3-303-308
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