ASSOCIATION BETWEEN ARTERIAL STIFFNESS AND CARDIOVASCULAR REMODELING DEPENDING ON BLOOD PRESSURE LEVEL
https://doi.org/10.18705/1607-419X-2014-20-3-166-171
Abstract
Objective. To study the indices of local arterial stiffness in correlation with structure-functional parameters of cardiovascular remodeling in healthy individuals and in hypertensive patients.
Design and methods. We carried out a cross-sectional population study in workers of an industrial enterprise. Altogether 213 people were enrolled, including 106 patients with arterial hypertension stage I–II and 107 healthy individuals. We assessed the stage and the grade of hypertension together with the additional categories of cardiovascular risk in accordance with national guidelines. All patients underwent echocardiography, ultrasound of the carotid arteries with simultaneous evaluation of arterial stiffness. Results. Hypertensive patients demonstrated a signiicant association between arterial stiffness indices and intima-media thickness (91 %) and echocardiographic parameters of the left heart volume.
Conclusion. The indices of arterial stiffness may serve as markers of effective management of risk factors in individuals with normal blood pressure and those of drug therapy in hypertensive patients.
About the Authors
O. Yu. Bastrikov
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
Corresponding author: the South Ural State Medical University, 64 Vorovskogo st., Chelyabinsk, Russia, 454092. E-mail: obastrikov@yandex.ru (Oleg Yu. Bastrikov, MD, PhD, an Associate Professor at the Department of Internal Diseases and Field Military Therapy at the South Ural State Medical University).
E. A. Grigoricheva
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
V. V. Belov
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
References
1. Vlachopoulos C., Aznaouridis K., Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis // J. Am. Coll. Cardiol. — 2010. — Vol. 55, № 13. — P. 1318–1327.
2. Mancia G., Laurent S., Agabiti-Roseic E. et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document // J. Hypert. — 2009. — Vol. 27, № 11. — P. 2121–2158.
3. Mitchell G.F., Hwang S.J., Vasan R.S. et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study //Circulation. — 2010. — Vol. 121, № 4. — P. 505–511.
4. Liao D., Arnett D.K., Tyroler H.A. et al. Arterial stiffness and the development of hypertension: the ARIC Study // Hypertension. — 1999. — Vol. 34, № 2. — P. 201–206.
5. Devereux R.B., Reichek N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method // Circulation. — 1977. — Vol. 55. — P. 613–618.
6. Roberto M.L., Bierig M., Devereux R.B. et al. Рекомендации по количественной оценке структуры и функции камер сердца // Рос. кардиол. журн. — Приложение 1. — 2012. — Т. 95, № 3. — С. 1–28. / Roberto M.L., Bierig M., Devereux R.B. et al. Guidelines on the assessment of structure and functions of heart chambers // Russian Cardiology Journal [Rossiyskiy Kardiologicheskiy Zhurnal]. — 2012. — Vol. 95, № 3. — Р. 1–28 [Russian].
7. Poli A., Tremoli E., Colombo A., Sirtori M., Pignoli P., Paoletti R. Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients: a new model for the quantiication and follow-up of pre-clinical atherosclerosis in living human subjects // Atherosclerosis. — 1988. — Vol. 70, № 3. — P. 253–261.
8. Laurent S., Cockcroft J., Van Bortel L. et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications // Eur. Heart J. — 2006. — Vol. 27, № 21. — P. 2588–2605.
9. Roman M.J., Pickering T.G., Schwartz J.E., Pini R., Devereux R.B. Relation of arterial structure and function to left ventricular geometric patterns in hypertensive adults // J. Am. Coll. Cardiol. — 1996. — Vol. 28, № 3. — P. 751–756.
10. Мельников И.Ю., Григоричева Е.А., Яшина Л.М. Сравнительная оценка локальной жесткости артерий у пациентов с гипертонической болезнью, ишемической болезнью сердца и сахарным диабетом // Регионарное кровообращение и микроциркуляция. — 2011. — Т. 38, № 2. — С. 53–57. / Melnikov I.Yu., Grigoricheva E.A., Yashina L.M. Comparative assessment of local arterial stiffness in patients with hypertension, coronary heart disease and diabetes mellitus // Regional Circulation and Microcirculation [Regionarnoye Krovoobrascheniye I Mikrotsirkulyatsiya]. — 2011. — Vol. 38, № 2. — Р. 53–57 [Russian].
11. Roman M.J., Ganau A., Saba P.S., Pini R., Pickering T.G., Devereux R.B. Impact of arterial stiffening on left ventricular structure // Hypertension. — 2000. — Vol. 36, № 4. — P. 489–494.
12. Kobayashi S., Yano M., Kohno M. et al. Inluence of aortic impedance on the development of pressure-overload left ventricular hypertrophy in rats // Circulation. — 1996. — Vol. 94, № 12. — P. 3362–3368.
Review
For citations:
Bastrikov O.Yu., Grigoricheva E.A., Belov V.V. ASSOCIATION BETWEEN ARTERIAL STIFFNESS AND CARDIOVASCULAR REMODELING DEPENDING ON BLOOD PRESSURE LEVEL. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2014;20(3):166-171. (In Russ.) https://doi.org/10.18705/1607-419X-2014-20-3-166-171
Views:
1061
Email this article 