The junctional adhesion molecule-А (JAM-A) and pathogenetic mechanisms of essential hypertension
https://doi.org/10.18705/1607-419X-2018-24-3-293-302
Abstract
Recent studies demonstrated an important role of the junctional adhesion molecule-A (JAM-A) in the pathogenesis of essential hypertension. Our studies showed higher content of JAM-A in women with essential hypertension. Also hypertensive women have higher levels of very low–density lipoprotein (VLDL), higher atherogenic index and lower concentrations of estrogen, progesterone and prolactin, indicating an increased risk of atherosclerosis and premature aging. By the laser speckle showed that the hemodynamic indices considerably change in essential hypertension. The levels of JAM-A correlate with blood pressure, lipids and hemodynamic indices, both in healthy subjects and in women with essential hypertension. The data demonstrate the importance of JAM-A in the pathogenesis of essential hypertension.
About the Authors
B. I. Kuznik
Chita State Medical Academy
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Department of Physiology,
39A Gorky street, Chita, 672000
S. O. Davydov
Chita State Medical Academy
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Department of Orthopaedic Surgery,
39A Gorky street, Chita, 672000
A. V. Stepanov
Chita State Medical Academy
Russian Federation
Russian Federation
MD, PhD, DSc, Head, Department of Emergency Medicine,
39A Gorky street, Chita, 672000
E. S. Guseva
Innovative Clinic “Health Academy”
Russian Federation
MD, PhD, Deputy Director on Innovations
Russian Federation
MD, PhD, Deputy Director on Innovations
Y. N. Smolyakov
Chita State Medical Academy
Russian Federation
Russian Federation
MD, PhD, Head, Department of Medical Physics,
39A Gorky street, Chita, 672000
I. V. Fine
Elfi-Tech Ltd
Israel
Israel
MD, General Director,
Rehovot
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Review
For citations:
Kuznik B.I., Davydov S.O., Stepanov A.V., Guseva E.S., Smolyakov Y.N., Fine I.V. The junctional adhesion molecule-А (JAM-A) and pathogenetic mechanisms of essential hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2018;24(3):293-302. (In Russ.) https://doi.org/10.18705/1607-419X-2018-24-3-293-302
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