RELATIONSHIP BETWEEN LEFT VENTRICULAR HYPERTROPHY AND REMODELING OF CAPILLARY NETWORK IN HYPERTENSIVE PATIENTS

Objective. Тo study relationship between left ventricular hypertrophy and peripheral capillary network remodeling in hypertensive patients with metabolic syndrome and without it.

Design and methods. The study included 33 hypertensive patients (51,4 ± 11,0) with and without metabolic syndrome (n = 12 and n = 21, respectively). The control group included healthy volunteers without cardiovascular pathology (n = 41). Besides routine clinical and laboratory examination all participants underwent vital nail-fold capillaroscopy to define density of capillary network and an assessment of remodeling coefficient (calculated as the ratio of the mean diameters of venous to arterial portions of capillaries). The left ventricular mass and index mass were estimated by echocardiographic technique.

Results. The study indicated change of capillary network: rarefaction and significant remodeling in hypertensive patients in comparison with healthy volunteers. Increased left ventricular index mass was predominant in hypertensive patients with metabolic syndrome (75 %) whereas it was found only in 27,3 % hypertensive patients without metabolic syndrome.

Conclusion. There was a correlation between blood pressure level and capillary network remodeling and between blood pressure level and left ventricular hypertrophy. Left ventricular hypertrophy was more frequent in hypertensive subjects with metabolic syndrome, whereas capillary network remodeling was not associated with presence of metabolic syndrome.

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