Бульбарный вазомоторный центр - морфофункциональная и нерохимическая организация
https://doi.org/10.18705/1607-419X-2003-9-3-77-81
Аннотация
Настоящий обзор посвящен анализу современных представлений о морфофункциональной и нейрохимической организации вентролатеральной части продолговатого мозга, в которой локализованы нейроны, осуществляющие регуляцию сосудистого тонуса и деятельности сердца. Представлены сведения об организации систем активации и торможения вазомоторных нейронов спинного мозга. Приводятся данные о роли норадреналина, адреналина, гамма-аминомасляной кислоты, глутамата, субстанции P как нейромедиаторов в регуляции кровообращения.
Об авторе
В. А. Цырлин
НИИ кардиологии им. В.А.Алмазова Минздрава России; Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Россия
Россия
Список литературы
1. Овсянников ФВ.(1971) Тонические и рефлекторные центры сосудистых нервов. Избр. произведения, M11955; 57-64-
2. Dittmar C. Uber die Hage des sogenannten Gejasscentrums in der Medulla oblongata. Ber Sachs Akad Wiss 1873; 25:449-69.
3. Вальдман А.В. Нейрофармакология центральной регуляции сосудистого тонуса. Л.: Медицина. 1976; 326 с.
4. Dampney RA, Moon EA. Role of ventrolateral medulla in vasomotor response to cerebral ischemia. Am J Physiol 1980; 239: H349-58. 5- Ciriello ), Caverson MM, Polosa C. Function of the ventrolateral medulla in the control of circulation. Brain Res 1986; 396 (4): 359-91.
5. Лебедев BIΊ. Вульбоспинальный уровень нервной регуляции сосудов. В кн.: Физиология кровообращения. Регуляция кровообращения.Л^ Наука. 1986; 230-71.
6. Amendt К, Cracburski J, Dembowsky К, Seller Н. Bulbospinal projections to the intermediolateral cell collumn; a neiiroanatomical stuffy. J Autonom Nerv Syst 1979; I (О- ЮЗ-17.
7. McAllen RM. Mediation of fastigial pressor response and a soma-tosympathetic reflex by ventral medullary neurones in the cat.J Physiol 1985; 368:423-33.
8. McAllen RM, May CN. Differential drives from rostral ventrolateral medullary neurons to three identified sympathetic out flows. Am J Physiol 1994; 267: R935-R944.
9. McAllen RM, May CN, Shafon AD. Functional anatomy of sympathetic premotor cell groups in the medullaClin Exp Hypertens 1995; П (1-2): 209-21.
10. McAllen RM, May CN, Campos RR. The supply of vasomotor drive to individual classes of sympathetic neuron. Clin Exp Hypertens 1997; 19(5-6): 607-18.
11. Dahlstrom Ą Fuxe K Evidance for the existence of monoamine containing neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal nervous system. Acta Physiol Scand 1965;64:7-85-
12. Swanson. Hartrnan BK. The central adrenergic system: an immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine - beta-hydroxylase as a marker.J Comp Neurol 1975; 163: 467-506.
13. Hokfelt T, Fuxe K, Goldstein MJohansson O. Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain. Brain Res 1974; 66: 235-61.
14. Jacobs BL, Gannon PJ, Azmitia EC. Atlas of serotoninergic cell bodies in the cat brainstem: an immunocytochemical analysis. Brain Res Bull 1984; 13:1-31.
15. Ciriello J, Caverson MM. Bidirectional cardiovascular connections between ventrolateral medulla and nucleus the solitary tract. Brain Res 1986; 367: 273-81.
16. Dahlstrom Ą Fuxe K Evidence for the existence of monoamine containing neurons in the central nervous system. !Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand 1964; 62 (suppl) 232:1-55.
17. Westlund KN, Bowker RM, Ziegler MG, Coulter JD. Noradrenergic projections to the spinal cord of the rat. Brain Res 1983; 263: 15-31.
18. Westlund KN, Bowker RM, Ziegler MG, CoulterJD. Originsandterminationsof descending noradrenergic projections to the spinal cord of monkey. Brain Res 1984; 292:1-16.
19. Ross CA, Ruggiero DA, Joh TH, Park DH, Reis DH. Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell columnfrom the region containing Cl adrenaline neurons. ) Comp Neurol 1984; 228:168-85.
20. Frics W, Zieglgansberger WA method to discriminate axonalfrom cell body activity and to analyse "silent" cells. Exp Brain Res 1974;21:441-5-
21. Campos RR, McAllen RM. Cardiac sympathetic premotor neurons. Am J Physiol 1997; 272: R6I-62O.
22. Scbreihofer AM, Stometta RL, Guyenet PG. Regulation of sympathetic tone and arterial pressure by rostral ventrolateral medulla after depletion of CI cells in rat. J Physiol 2000; 529: 221-36.
23. Lorenz RG, Saper CB, Wong DL, Ciaranello RD, Loewy AD. Co-localization of substance-P and phenyletbanolamine -N- methyl - transferase - like immunoreactivity in neurons of ventrolateral medulla that project to the spinal cord: potential role in control of vasomotor tone. Neuroscie Lett 1985; 55: 255-60.
24. Gebber CL. Central determinans of sympathetic nerve discharge. In: Central Regulation of Autonomic Functions, ed.ADLoewy and KM.Granata, 1983.
25. Helke CJ, Chariton CG, Keeler JR. Bulbospinal substance P and sympathetic regulation of the cardiovascular system: a review. Peptides, 1985; 6 (suppl. 2): 69-74-
26. Helke CJ, Neil JJ, Massari VJ, Loewy AD. Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat. Brain Res 1982; 243:147-52.
27. Tokano Y, Martin JE, Leeman SE, Loeuy AD. Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure. Brain Res 1984; 291: 168-72.
28. Backman SB, Henry JL Effects of substance P and thyrotropin - releasing hormone on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat. CanJ Physiol Pharmacol 1984; 62:248-51.
29. Krukoff TL, CirieUo J, Calaresu FR. Segmental distribution of peptide- and 5 HT-Iike immunoreactivity in nerve terminals andfibers of the thoraco - lumbar sympathetic nuclei of the cat. J Comp Neurol 1985; 240:103-16.
30. Milner TĄ Pickel VM, Morrison SF, Reis DJ. Adrenergic neurons in the rostral ventrolateral medulla: ultrastructure and synaptic relations with other transmitte identified neurons. ProgBrain Res 1989; 81:29-47-
31. Morrison SF, Callaway ), Milner TA, Reis DJ. Glutamate in the spinal sympathetic intermediolateral nucleus: localization by light and electron microscopy. BrainRes 1989;503 (I):5-15.
32. Morrison SF, Callaway J, Milner TA, Reis DJ. Rostral ventrolateral medulla: a source of the glutarnatergi innervation of the sympathetic intermediolateral nucleus. Brain Res, 1991; 562 (I): 126-35.
33. Morrison SF, Milner TA, Reis DJ. Reticulospinal vasomotor neurons of the ratrostral ventrolateral medulla: relationship to sympathetic nerve activity and the C1 adrenergic cell group J Neurosci 1988; 8 (4): 1286-301.
34. Reis DJ, Golanov EV, Ruggiero DĄ Sun MK. Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations.] Hypertens Suppl 1994; 12 (10): S159-80.
35. Spyer KM. The central nervous organization of reflex circulatory control Jn: Central Regulation of Autonomic Function, ed. Loewy AD, Spyer KM. Oxford University Press,NY. 1990; 126-44-
36. Spyer KM. Central nervous mechanisms contributing to cardiovascular control.] Physiol 1994,474 (I).· 1-19.
37. Jones BE, Friedman L.Atlas of catecholamine perikaria, varicosities ana pathways in the brainstem of the cat. J Comp Neurol 1983; 215- 382-96.
38. Loewy AD, Wallach JH, McKellar S. Efferent connections of the ventral medulla oblongata in the rat. Brain Res Rev 1981; 3: 63-SO.
39. King GW. Topology of ascending brainstem projections to nucleus parabrachialis in the cat.J Comp Neurol 1980; 191:615-38.
40. Sakai K, Touret M, Salvert D, Leger L,Jouvet M. Afferent projections to the cat locus coeruleus as visualized by the horseradish peroxidase technique. Brain Res 1977;119:21-41.
41. Saper CB, Loeivy AD, Swanson LW, Cowan WH. Direct hypothalamoautonomic connections. Brain Res 1976; 117:305-12.
42. Ruggiero DĄ Ross CA, Anwar M et al. The rostral ventrolateral medulla: immunocytochemistry ofintrinsicneurons and afferent connections. Soc Neurosci Abstr 1984; 10:299·'
43. Schlaefke ME. Central chemosensitivity a respiratory drive. Rev Physiol BiochemPharmacol 1981; 90:171-244.
44. Feldberg W, Guertzenstein PG. A vasodepressor effect of pentobarbitone sodi-um.J Physiol 1972; 224:83-103.
45. Guertzenstein PG, SilverA Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions.J Physiol 1974; 242:489-503.
46. Willette RN, Barcas PP, Krieger AJ ,Sapnt NH. Endogenous GABAergic mechanisms in the VLM and the regulation of bloodpressure. Soc Neurosci Abstr 1983; 9:550.
47. Edery H. Target sites for anticholinesterase, cholinolytics and oximes on ventral medulla oblongata. In: Central Neurone Environment, ed. Sehlaef ME, Koepchen YP: Berlitv Springer, 1983; 238-50.
48. Punnen S, Willette RN, KriegerAf, Sapru HN. Cardiovascidar response to injections of enkephalin in the pressor area of the ventrolateral medulla. Brain Res 1984; 23:939-46.
49. Красюков A.B., Лебедев В.П. Никитин C.A. Ответы в белых соедини-тельных веточках разных сегментов спинного мозга при стимуляции вентральной поверхности продолговатого мозга. Физиолжурн. СССР. 1982; 68 (8): 1057-65
50. Barman SM, Geber GLAxonal projection patterns of ventrolateral medullospinal sympathoexcitatory neurons. Neurophysiol 1985; 53 (6): 1551-66.
51. Yoshimura M, Polosa C, Nishi S. Noradrenaline modifies sympathetic pregan -glionic neuron spike and afterpotential. Brain Res 1986:362 (2): 30-4
52. InokuchiH,Yoshimura M,Polosa C, Nishi S.Adrenergic receptors (alpha I and alpha 2) modulate differ potassium conductances in sympathetic preganglionic neurons. Can J Physiol Pharmacol 1992; 70 (suppL): S92
53. Yoshimura M, Polosa C, Nishi S. Electmpbysiological properties of sympathetic preganglionic neurons in the cat spinal cord in vitro. Pflugers Arcb 1986: 406 (2): 91-8.
54. Inokuchi H, Yoshimura M, Polosa C, Nishi S. Heterogeneity of the afierbyperpo-larization of sympathetic preganglionic neurons. Kurume Med J 1993:40 (4): 177-81.
55. Inokuchi H, Yoshimura M,Yamada S, Polosa C, Sisbi S. Membranepropertis and dendritic arborization of the intermediolateral nucleus neurons in the guinea-pigyhoracispinal cord in vitro.J Auton NervSyst 1993:43 (2): 9-106.
56. Deuchars SA, Morrison SF, Gilbey MP. Medullary - et xjked EPSPs inneonatal ratsumpatheticpreganglionic neurons in vitro.JPhysiol 1995:487 (pt 2): 453-63.
57. Aicher SA, Reis DJ, Nicolae R, Milner TA Monosynaptic projections from the medullary gigantocellular reticular formation to sympathetic preganglionic neurons in thoracic spinal cord J Comp Neurol 1995; 363 (4): 563-80.
58. McAllen RM, Habler HJ, Michaelis M, Peters OJanig W. Monosynaptic excitation of preganglionic vasomotor neurons by subretrofacial neurons of the rostral ventrolateral medulla. Brain Res 1994; 634:227-34
59. Zagon A, Smith AD. Monosynaptic projectionsfrom the rostral ventrolateral medulla oblongata to identified sympathetic preganglionic neurons. Neuroscience 1993; 54 (3): 729-43
60. Seller H, IUert M. The localization of the first synapse in the carotid sinus baroreceptor reflex pathways and its alteration of the afferent input. Pflugers Arch 1969:306:1-19.
61. Brooks PA, Izzo PN, Spyer KM. Brain stem GABA pathways and the regula-tion ofbaroreflex activity. In: Central Neural Mechanisms in Cardiovascular Regulation, ed. Kunos G, CirieUo J. 1993; 2:321 -37.
62. Bousquet P,Feldman J, Bloch R, SchwartzJ. Evidencefora neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivativies injected into the NTS. N-S. Arch Pharmacol 1982; 319: I68-71
63. Lewis DI, Coote JH. Baroreceptor induced inhibition of sympathetic neurons by gaba acting at a spinal site, APStracts 1995; 2:0515H.
64. Лебедев B.H., Баклаваджан О.Г.,Химониди Р.К. Уровень реализации барорефлекторного симпато-ингибиторного эффекта. Физиол. журн. СССР. 1980; 66 (7): 1015-23.
65. Jeske I, Morrison SE, Cravo SL, Reis DJ. Identification of baroreceptor reflex intemeurones in the cat ventrolateral medulla.Am J Physiol 1993; 264:169-78.
66. Willette RN, Barcas PP, Krieger AJ, Sapru HN. Neutropharmacologv, 1983; 22: 1071-9
Рецензия
Для цитирования:
Цырлин В.А. Бульбарный вазомоторный центр - морфофункциональная и нерохимическая организация. Артериальная гипертензия. 2003;9(3):77-81. https://doi.org/10.18705/1607-419X-2003-9-3-77-81
For citation:
Cirline V.A. Vasomotor centre of medulla - morpho-functional and neurochemical organization. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2003;9(3):77-81. (In Russ.) https://doi.org/10.18705/1607-419X-2003-9-3-77-81
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