Vasomotor centre of medulla - morpho-functional and neurochemical organization
https://doi.org/10.18705/1607-419X-2003-9-3-77-81
Abstract
The analysis of ventrolateral medulla morpho-functional and neurochemical organization is the aim of this survey. The date on the system of activation and inhibition of the spinal cord vasomotor neurons is represented. In addition, we discuss the role of catecholamines, substance P, glutamate, gamma-aminobutiric acid as neuromediators in the regulation of circulation.
About the Author
V. A. Cirline
НИИ кардиологии им. В.А.Алмазова Минздрава России; Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
References
1. Овсянников ФВ.(1971) Тонические и рефлекторные центры сосудистых нервов. Избр. произведения, M11955; 57-64-
2. Dittmar C. Uber die Hage des sogenannten Gejasscentrums in der Medulla oblongata. Ber Sachs Akad Wiss 1873; 25:449-69.
3. Вальдман А.В. Нейрофармакология центральной регуляции сосудистого тонуса. Л.: Медицина. 1976; 326 с.
4. Dampney RA, Moon EA. Role of ventrolateral medulla in vasomotor response to cerebral ischemia. Am J Physiol 1980; 239: H349-58. 5- Ciriello ), Caverson MM, Polosa C. Function of the ventrolateral medulla in the control of circulation. Brain Res 1986; 396 (4): 359-91.
5. Лебедев BIΊ. Вульбоспинальный уровень нервной регуляции сосудов. В кн.: Физиология кровообращения. Регуляция кровообращения.Л^ Наука. 1986; 230-71.
6. Amendt К, Cracburski J, Dembowsky К, Seller Н. Bulbospinal projections to the intermediolateral cell collumn; a neiiroanatomical stuffy. J Autonom Nerv Syst 1979; I (О- ЮЗ-17.
7. McAllen RM. Mediation of fastigial pressor response and a soma-tosympathetic reflex by ventral medullary neurones in the cat.J Physiol 1985; 368:423-33.
8. McAllen RM, May CN. Differential drives from rostral ventrolateral medullary neurons to three identified sympathetic out flows. Am J Physiol 1994; 267: R935-R944.
9. McAllen RM, May CN, Shafon AD. Functional anatomy of sympathetic premotor cell groups in the medullaClin Exp Hypertens 1995; П (1-2): 209-21.
10. McAllen RM, May CN, Campos RR. The supply of vasomotor drive to individual classes of sympathetic neuron. Clin Exp Hypertens 1997; 19(5-6): 607-18.
11. Dahlstrom Ą Fuxe K Evidance for the existence of monoamine containing neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal nervous system. Acta Physiol Scand 1965;64:7-85-
12. Swanson. Hartrnan BK. The central adrenergic system: an immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine - beta-hydroxylase as a marker.J Comp Neurol 1975; 163: 467-506.
13. Hokfelt T, Fuxe K, Goldstein MJohansson O. Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain. Brain Res 1974; 66: 235-61.
14. Jacobs BL, Gannon PJ, Azmitia EC. Atlas of serotoninergic cell bodies in the cat brainstem: an immunocytochemical analysis. Brain Res Bull 1984; 13:1-31.
15. Ciriello J, Caverson MM. Bidirectional cardiovascular connections between ventrolateral medulla and nucleus the solitary tract. Brain Res 1986; 367: 273-81.
16. Dahlstrom Ą Fuxe K Evidence for the existence of monoamine containing neurons in the central nervous system. !Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand 1964; 62 (suppl) 232:1-55.
17. Westlund KN, Bowker RM, Ziegler MG, Coulter JD. Noradrenergic projections to the spinal cord of the rat. Brain Res 1983; 263: 15-31.
18. Westlund KN, Bowker RM, Ziegler MG, CoulterJD. Originsandterminationsof descending noradrenergic projections to the spinal cord of monkey. Brain Res 1984; 292:1-16.
19. Ross CA, Ruggiero DA, Joh TH, Park DH, Reis DH. Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell columnfrom the region containing Cl adrenaline neurons. ) Comp Neurol 1984; 228:168-85.
20. Frics W, Zieglgansberger WA method to discriminate axonalfrom cell body activity and to analyse "silent" cells. Exp Brain Res 1974;21:441-5-
21. Campos RR, McAllen RM. Cardiac sympathetic premotor neurons. Am J Physiol 1997; 272: R6I-62O.
22. Scbreihofer AM, Stometta RL, Guyenet PG. Regulation of sympathetic tone and arterial pressure by rostral ventrolateral medulla after depletion of CI cells in rat. J Physiol 2000; 529: 221-36.
23. Lorenz RG, Saper CB, Wong DL, Ciaranello RD, Loewy AD. Co-localization of substance-P and phenyletbanolamine -N- methyl - transferase - like immunoreactivity in neurons of ventrolateral medulla that project to the spinal cord: potential role in control of vasomotor tone. Neuroscie Lett 1985; 55: 255-60.
24. Gebber CL. Central determinans of sympathetic nerve discharge. In: Central Regulation of Autonomic Functions, ed.ADLoewy and KM.Granata, 1983.
25. Helke CJ, Chariton CG, Keeler JR. Bulbospinal substance P and sympathetic regulation of the cardiovascular system: a review. Peptides, 1985; 6 (suppl. 2): 69-74-
26. Helke CJ, Neil JJ, Massari VJ, Loewy AD. Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat. Brain Res 1982; 243:147-52.
27. Tokano Y, Martin JE, Leeman SE, Loeuy AD. Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure. Brain Res 1984; 291: 168-72.
28. Backman SB, Henry JL Effects of substance P and thyrotropin - releasing hormone on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat. CanJ Physiol Pharmacol 1984; 62:248-51.
29. Krukoff TL, CirieUo J, Calaresu FR. Segmental distribution of peptide- and 5 HT-Iike immunoreactivity in nerve terminals andfibers of the thoraco - lumbar sympathetic nuclei of the cat. J Comp Neurol 1985; 240:103-16.
30. Milner TĄ Pickel VM, Morrison SF, Reis DJ. Adrenergic neurons in the rostral ventrolateral medulla: ultrastructure and synaptic relations with other transmitte identified neurons. ProgBrain Res 1989; 81:29-47-
31. Morrison SF, Callaway ), Milner TA, Reis DJ. Glutamate in the spinal sympathetic intermediolateral nucleus: localization by light and electron microscopy. BrainRes 1989;503 (I):5-15.
32. Morrison SF, Callaway J, Milner TA, Reis DJ. Rostral ventrolateral medulla: a source of the glutarnatergi innervation of the sympathetic intermediolateral nucleus. Brain Res, 1991; 562 (I): 126-35.
33. Morrison SF, Milner TA, Reis DJ. Reticulospinal vasomotor neurons of the ratrostral ventrolateral medulla: relationship to sympathetic nerve activity and the C1 adrenergic cell group J Neurosci 1988; 8 (4): 1286-301.
34. Reis DJ, Golanov EV, Ruggiero DĄ Sun MK. Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations.] Hypertens Suppl 1994; 12 (10): S159-80.
35. Spyer KM. The central nervous organization of reflex circulatory control Jn: Central Regulation of Autonomic Function, ed. Loewy AD, Spyer KM. Oxford University Press,NY. 1990; 126-44-
36. Spyer KM. Central nervous mechanisms contributing to cardiovascular control.] Physiol 1994,474 (I).· 1-19.
37. Jones BE, Friedman L.Atlas of catecholamine perikaria, varicosities ana pathways in the brainstem of the cat. J Comp Neurol 1983; 215- 382-96.
38. Loewy AD, Wallach JH, McKellar S. Efferent connections of the ventral medulla oblongata in the rat. Brain Res Rev 1981; 3: 63-SO.
39. King GW. Topology of ascending brainstem projections to nucleus parabrachialis in the cat.J Comp Neurol 1980; 191:615-38.
40. Sakai K, Touret M, Salvert D, Leger L,Jouvet M. Afferent projections to the cat locus coeruleus as visualized by the horseradish peroxidase technique. Brain Res 1977;119:21-41.
41. Saper CB, Loeivy AD, Swanson LW, Cowan WH. Direct hypothalamoautonomic connections. Brain Res 1976; 117:305-12.
42. Ruggiero DĄ Ross CA, Anwar M et al. The rostral ventrolateral medulla: immunocytochemistry ofintrinsicneurons and afferent connections. Soc Neurosci Abstr 1984; 10:299·'
43. Schlaefke ME. Central chemosensitivity a respiratory drive. Rev Physiol BiochemPharmacol 1981; 90:171-244.
44. Feldberg W, Guertzenstein PG. A vasodepressor effect of pentobarbitone sodi-um.J Physiol 1972; 224:83-103.
45. Guertzenstein PG, SilverA Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions.J Physiol 1974; 242:489-503.
46. Willette RN, Barcas PP, Krieger AJ ,Sapnt NH. Endogenous GABAergic mechanisms in the VLM and the regulation of bloodpressure. Soc Neurosci Abstr 1983; 9:550.
47. Edery H. Target sites for anticholinesterase, cholinolytics and oximes on ventral medulla oblongata. In: Central Neurone Environment, ed. Sehlaef ME, Koepchen YP: Berlitv Springer, 1983; 238-50.
48. Punnen S, Willette RN, KriegerAf, Sapru HN. Cardiovascidar response to injections of enkephalin in the pressor area of the ventrolateral medulla. Brain Res 1984; 23:939-46.
49. Красюков A.B., Лебедев В.П. Никитин C.A. Ответы в белых соедини-тельных веточках разных сегментов спинного мозга при стимуляции вентральной поверхности продолговатого мозга. Физиолжурн. СССР. 1982; 68 (8): 1057-65
50. Barman SM, Geber GLAxonal projection patterns of ventrolateral medullospinal sympathoexcitatory neurons. Neurophysiol 1985; 53 (6): 1551-66.
51. Yoshimura M, Polosa C, Nishi S. Noradrenaline modifies sympathetic pregan -glionic neuron spike and afterpotential. Brain Res 1986:362 (2): 30-4
52. InokuchiH,Yoshimura M,Polosa C, Nishi S.Adrenergic receptors (alpha I and alpha 2) modulate differ potassium conductances in sympathetic preganglionic neurons. Can J Physiol Pharmacol 1992; 70 (suppL): S92
53. Yoshimura M, Polosa C, Nishi S. Electmpbysiological properties of sympathetic preganglionic neurons in the cat spinal cord in vitro. Pflugers Arcb 1986: 406 (2): 91-8.
54. Inokuchi H, Yoshimura M, Polosa C, Nishi S. Heterogeneity of the afierbyperpo-larization of sympathetic preganglionic neurons. Kurume Med J 1993:40 (4): 177-81.
55. Inokuchi H, Yoshimura M,Yamada S, Polosa C, Sisbi S. Membranepropertis and dendritic arborization of the intermediolateral nucleus neurons in the guinea-pigyhoracispinal cord in vitro.J Auton NervSyst 1993:43 (2): 9-106.
56. Deuchars SA, Morrison SF, Gilbey MP. Medullary - et xjked EPSPs inneonatal ratsumpatheticpreganglionic neurons in vitro.JPhysiol 1995:487 (pt 2): 453-63.
57. Aicher SA, Reis DJ, Nicolae R, Milner TA Monosynaptic projections from the medullary gigantocellular reticular formation to sympathetic preganglionic neurons in thoracic spinal cord J Comp Neurol 1995; 363 (4): 563-80.
58. McAllen RM, Habler HJ, Michaelis M, Peters OJanig W. Monosynaptic excitation of preganglionic vasomotor neurons by subretrofacial neurons of the rostral ventrolateral medulla. Brain Res 1994; 634:227-34
59. Zagon A, Smith AD. Monosynaptic projectionsfrom the rostral ventrolateral medulla oblongata to identified sympathetic preganglionic neurons. Neuroscience 1993; 54 (3): 729-43
60. Seller H, IUert M. The localization of the first synapse in the carotid sinus baroreceptor reflex pathways and its alteration of the afferent input. Pflugers Arch 1969:306:1-19.
61. Brooks PA, Izzo PN, Spyer KM. Brain stem GABA pathways and the regula-tion ofbaroreflex activity. In: Central Neural Mechanisms in Cardiovascular Regulation, ed. Kunos G, CirieUo J. 1993; 2:321 -37.
62. Bousquet P,Feldman J, Bloch R, SchwartzJ. Evidencefora neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivativies injected into the NTS. N-S. Arch Pharmacol 1982; 319: I68-71
63. Lewis DI, Coote JH. Baroreceptor induced inhibition of sympathetic neurons by gaba acting at a spinal site, APStracts 1995; 2:0515H.
64. Лебедев B.H., Баклаваджан О.Г.,Химониди Р.К. Уровень реализации барорефлекторного симпато-ингибиторного эффекта. Физиол. журн. СССР. 1980; 66 (7): 1015-23.
65. Jeske I, Morrison SE, Cravo SL, Reis DJ. Identification of baroreceptor reflex intemeurones in the cat ventrolateral medulla.Am J Physiol 1993; 264:169-78.
66. Willette RN, Barcas PP, Krieger AJ, Sapru HN. Neutropharmacologv, 1983; 22: 1071-9
Review
For citations:
Cirline V.A. Vasomotor centre of medulla - morpho-functional and neurochemical organization. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2003;9(3):77-81. (In Russ.) https://doi.org/10.18705/1607-419X-2003-9-3-77-81
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