Combined pharmacotherapy for arterial hypertension in patients with type 2 diabetes mellitus

Abstract

The antihypertensive effects and tolerance of a fixed low-dose combination of the angiotensin-converting enzyme (ACE) inhibitor perindopril, 2 mg, and the diuretic indapamide, 0.025 mg (noliprel), were studied in patients with mild and moderate arterial hypertension associated with diabetes mellitus. The patients' mean age was 51.36 ± 6.11 years, Hblc was 7.86 ± 1.73 %. The antihypertensive effects were evaluated from the results of daily blood pressure monitoring following 16 weeks of therapy. It was found that noliprel exerted a multidirectional corrective effect on the daily blood pressure (BP): it provided a significant optimal BP lowering during a clay on a long-term basis; significantly normalized the pressure load index in day- and night-time; significantly diminished the baseline increased systolic and diastolic BP variabilities during a day. normalized the impaired two-phase BD profile. The efficiency of treatment was 100 %, as evidenced by clinical BP and diurnal BP profile; the achievement of targeted BP was 88 % by the end of therapy. During therapy with the agent, stable glycemia control preserved and there was no negative effect on the lipid spectrum, which permits the use of the drug in patients with arterial hypertension concurrent with metabolic disorders.