Open comparative controlled study of the use of the calcium antagonists nifedipine SR/GITS and amlodipine in patients with hypertensive disease
https://doi.org/10.18705/1607-419X-2004-10-4-197-201
Abstract
An open comparative controlled study of the use of the calcium antagonists nifedipine SR/GITS and amlodipine was conducted in patients with hypertensive disease. The results suggest that both drugs have a high and stable antihypertensive activity during a day: they are sale and produce a positive effect on the life quality in the patients. Therapy in both groups improved the parameters of heart rate variability and daily blood pressure profile, which are important risk factors of the progression of cardiovascular diseases and their mortality. However, it should be noted that there was a more marked antihypertensive effect and a more Significant improvement of heart rate variability parameters in the nifedipine SR/GITS group than in the amlodipine group.
About the Authors
N. E. Zvartau
Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
O. P. Rotar
Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
I. V. Yemelyanov
Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
A. O. Konradi
Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
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Review
For citations:
Zvartau N.E., Rotar O.P., Yemelyanov I.V., Konradi A.O. Open comparative controlled study of the use of the calcium antagonists nifedipine SR/GITS and amlodipine in patients with hypertensive disease. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2004;10(4):197-201. (In Russ.) https://doi.org/10.18705/1607-419X-2004-10-4-197-201
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