Calcium antagonists: principals of therapy in the light of evidence based studies data
https://doi.org/10.18705/1607-419X-2004-10-1-43-45
Abstract
Calcium antagonists (CA) are the group of drugs the main property of which are the ability to inhibit calcium influx through the so-called slow calcium channels. According to chemical structure, CA are divided into dihydropyridines (nifedipine, amlodipine, felodipine) and nondihydropyridines (verapamil and diltiazem). CA are also divided into first generation agents (conventional tablets) and second generation agents (long acting agents), the last are not only more convenient bat also more safe drugs. The data of large randomised trials confirm that CA have favorable effect on life prognosis during their regular administration to patients with arterial hypertension, this effect of CA is similar to that of other antihypertensive drugs (AHD). However, CA may be superior to other AHD in preventing stroke and inferior to other AHD in preventing myocardial infarction and congestive heart failure.
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Review
For citations:
Marcevich M.U. Calcium antagonists: principals of therapy in the light of evidence based studies data. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2004;10(1):43-45. (In Russ.) https://doi.org/10.18705/1607-419X-2004-10-1-43-45
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