Effect of insulin on the functional status of the pituitary-gonadal system In males with arterial hypertension
https://doi.org/10.18705/1607-419X-2004-10-1-46-48
Abstract
The study was undertaken to examine the metabolism and blood levels of major adrenal and gonadal androgens and the relationship between the levels of insulin and major steroid hormones in males with untreated arterial hypertension (AH). A hundred and twenty-five patients with AH and 15 healthy males matched by age who made up a control group. The males with AH had low levels of free testosterone, dihydroepiandrosterone sulfate and high concentrations of insulin as compared with the control group. The values of gonadotropic hormones, estradiol and cortisol did not differ in the comparable groups. There was a negative correlation between the levels of free testosterone, dihydroepiandrosterone sulfate, and insulin in patients with AH.
About the Authors
N. V. Ivanov
городская больница Святой Преподобномученицы Елизаветы
Russian Federation
Russian Federation
N. V. Vorokhobina
Санкт-Петербургская медицинская академия последипломного образования
Russian Federation
Russian Federation
S. K. Churina
Институт физиологии И.П.Павлова РАН
Russian Federation
Russian Federation
References
1. Reaven GM. Treatment of hypertension: focas on prevention of coronary heart disease.J Clin Endocrinol Metab 1993; 76:53 7-40.
2. Ferrannini E, Buzzigoli G, Bonadonna R et al. Insulin resistance in essential hypertension. N Engl J Med 1997; 317:350- 7.
3. Grandi AM, Zanzi P, Broggi R et al. Longitudinal Changes ofInsulin Sensitivity in Essential Hypertension: Influence of Blood Pressure Control and Familial Predisposition to Hypertension.J Clin Endocrinol Metab 2001; 86:3027-31-
4. Nestler JE, Clore JN, Blackard WG. Debydroepiandrosterone: the “missing link ” between byperinsulinemia and atherosclerosis?FASEBJ1992; 6:3073-5-
5. Jaffe A, Chen Y et al. Erectile dysfunction in hypertensive male. Assessment of potential determinants. Hypertension 1996; 28:859-62.
6. Channer KS, Jones TH. Cardiovascular effects of testosterone: implications of the "male menopause"?. Heart 2003; 89:121-2.
7. English KMJones RD et al. Testosterone acts as coronary vasodilatators by a calcium channel antagonist action. J Endocrinol Invest 2002; 25:455-8.
8. English KM, Steeds RP et al. Low dose transdermal testosterone therapy improves angina threshold m men with chronic stable angina. Circulation 2000; 102:1906-11.
9. Yen SCS. Dehydroepiatidrosterone sulfate and longevity: new clue for an old friend, PNAS 2001; 98: 8167-9-
10. WorldHealth Organization - International Society of Hypertension Guidelinesfor tbe Management of HypertensionJ Hypertens 1999; 17:151-83.
11. Сахарный диабет: доклад исследовательской группы ВОЗ. M, 1987-
12. Caro JF. Insulin resistance in obese and nonobese man. J Clin Endocrinol Metab 1991; 73:691-5.
13. Sufi SB, Donaldson Ą Jeffcoute SL. WHO Matched Reagent Programme Method Manual 16th ed. London, 1992.
14. Fogary R, ZoppiĄ Preti P et al. Sexual activity andplasma testosterone levels in hypertensive males. Am J Hypertens 2002; 15:271—4-
15. Ворохобина HB. Функциональное состояние системы гипоталамусгипофиз-гонады у мужчин с различной эндокринной патологией. Дис.. д-рамед. наук. СПб, 1997-
16. Lin Т, Haskell Yб Vinson N, Terracio L Characterization of insulin and insulin like growth factor I receptor of purified Leydig cells and their role in steroidogenesis in primary culture: comparative study. Endocrinology 1986; 119:1641-7.
17. Vermeulen Ą Kaufmannn JM, Deslypere JP, Thomas G. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in h)>pogonadism of obese menJ Clin Endocrinol Metab. 1993; 76: II4O-6.
18. Poretsky L, Kalin MF. The gonadotropic Jimction of insulin. Endocr Rev 1987; 8: ІЗ2-4І.
19. Zelissen PMS, Koppeschaar HPF, Erkelens DW, Thyssen JHH. ß-Endorphin and adrenocortical function in obesity. Clin Endocrinol(Oxf) 1991;35:369-72.
20. Gugliano Ď. Morphine, opioid peptides and pancreatic isletJunction. Diabetes Care 1984; 7:92-8.
21. Sowers JR, Nyby N, Jasberg K Dopaminergic control of prolactine and blood pressure: altered control in essential hypertension. Hypertension 1982; 4:431 -5.
22. Strain GW, Zumoff B, Strain JJ et al. Cortisol production in obesity. Metabolism 1980;29:980-5.
23. Rosenfeld RS, Rosenberg BJ, Fukushima DK, Heilman L. 24-Hour secretary pattem of debydroepiandrosterone and detydroepiandrosterone sulfate. J CUn Endocrinol Metab 1975; 40: 850-5-
24. Nestler JE, McClanahan MA, Clore JN, Blackard WG. Insulin inhibits adrenal 1720-lyase activity in man.J Clin Endocrinol Metab 1992; 74.ś 362-7-
25. Giagulli AV, Kaufman JM, VermeulenA Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994; 79:997-1000.
Review
For citations:
Ivanov N.V., Vorokhobina N.V., Churina S.K. Effect of insulin on the functional status of the pituitary-gonadal system In males with arterial hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2004;10(1):46-48. (In Russ.) https://doi.org/10.18705/1607-419X-2004-10-1-46-48
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