Nitric oxide (NO) is a paramagnetic molecule, îe a free radical, and, under poor metabolic conditions, can induce the so-called nitrosylating stress HPLC was used to study an increase of the lipid peroxidation (LPO) product malonic dialdehyde when the NO donor mtrosoglutathione was administered to experimental rats Chromatographic analysis was made on an Agilent-1100 liquid chromatograph (Agilent Technologies, Germany) The effect of mtrosogluthatione was compared with that of a mixture of ferrous mtrile acetate and homocystine given to the animals as a prooxidant Under experimental oxidative stress after administration of ferrous mtrile and homocystine (40 mkmole/kg, calculated with reference to iron), the rat blood serum level of malonic dialdehyde increased by approximately 20 times as compared to that in the control group of animals Four-fold activation of malonic dialdehyde formation was revealed in rats under nitrosothiol oxidation (after administration of mtrosogluthatione in a dose of 200 mkmole/kg) It is concluded that NO donors are able to induce oxidative stress When NO donors are used in long-term therapy, it is necessary to control the body’s oxidative status

Objective To study the effects of moexipril on the level of blood pressure (BP), the course of the postmenopausal syndrome and the changes occurring in bony tissue in females with mild and mild hypertension in postmenopause Materials and methods Thirty-five females with arterial hypertension were examined All the females were observed to have the menopausal syndrome and reduced bone mineral density To study the effect of moexipril, changes in BP were assessed by its rou tine measurements by means of a sphygmomanometei during control visits before and 1, 3, 6, and 12 months after therapy and by the records available in the BP diaries, bone density was determined by bone ultrasound densitometry before and 12 months after the study Results There was a significant reduction in systolic and diastolic BP by months 1 and 3 of moexipril therapy The manifestations of the menopausal syndrome attenuated by month 6 By the end of the study, the drug showed a significant antiosteopemc activity in the treated females as compared with the untreated ones (p<0,01) Moexipril therapy caused a significant clinical improvement (p<0,05) and a decrease in the degree of reactive anxiety (p<0 05) and depression Conclusion Moexipril is an effective antihypertensive drug whose use normalizes BP in most patients, well tolerated, attenuates the menopausal syndrome, exerts a beneficial effect on bone metabolism The major advantage of the drug is that it can be widely used in postmenopausal women with essential hypertension

The paper presents the data available in the literature and the authors' findings on the role of ß-blockers in the treatment of arterial hypertension, on negative metabolic effects, and ways of their overcome The advantages of nebivolol in the treatment of essential hypertension are demonstrated The data of the SENIORS study on the beneficial effects in the treatment of elderly patients with heart failure are given

To study early impairments in the elastic properties of the vascular wall in arterial hypertension (AH), 32 hypertensive patients of young age (18,9±2,6 years) were examined, a control group comprised 35 healthy young males of the same age Doppler ultrasound study (DUSS) of the common carotid (CC), brachial, and radial arteries was performed and CC wall elasticity modules, aortic compliance, and pulse wave velocity (PWV) were estimated Analyzing the results of DUSS in patients with AH revealed no significant differences in velocity parameters and in the values of peripheral resistance The estimation of the elasticity module at rest and during functional tests demonstrated a less increment in this parameter in patients with AH during exercise than in the control group Elasticity module changes were heteiodirectional during nitroglycerine tests The estimation of PWV revealed a significant increase in this parameter, which was indicative of early impairments in the elastic properties of the vascular wall The high informative \ alue and technical simplicity permit the use of PWV as a screening of vascular wall lesion in patients with AH

Objective to evaluate the efficacy and tolerability of fixed low-dose combination of permdopnl and indapamide and its co-administration with hormonal replacement therapy in women with postmenopausal hypertensive disease Materials and methods 63 women with grade 1-2 essential hypertension and postmenopausal syndrome were examined The patients were randomized to receive antihypertensive therapy with noliprel (Group 1) or its combination with hormonal replacement therapy (Group 2) The authors made blood pressure (BP) measurements by the Korotkoff method, 24-hour BP monitoring, echocardiography, studied the lipid spectrum, the plasma levels of glucose, creatinine, potassium, and uric acid, and determined life quality with the modified menopausal index Results A good subjective tolerability of therapy and a decrease in the menopausal index were noted in both groups The efficiency of antihypertensive therapy was 92 7% in Group 1 and 95 2% in Group 2 24-hour BP monitoring showed that the reduction in BP and pressure load was significantly higher in Group 2 than in Group 1 The therapy has no negative impact on metabolic parameters in both groups Conclusion Thus, noliprel is an effective drug in treating postmenopausal women with hypertensive disease Hormonal replacement therapy contributes to the higher antihypertensive effect of noliprel and exerts no effect on its metabolic neutrality

The physiological, psychological, and behavioral features under emotional stress were compared in 44 patients with Stage II hypertensive disease (HD) (including 22 patients with the so-called office hypertension and 22 patients with the equal values of blood pressure (BP) on a working day and a day-off) and in 30 age and gender-matched healthy individuals During emotional stress, patients with HD had a significantly great rise in systolic BP as compared with healthy individuals (on the average by 11 and 3 mm Hg, respectively) The claims made by these patients were characterized by a rather great extent, instability and then nonverbal behavior was marked by a significantly large number of gestures and by altered voice tone as compared with the healthy individuals As compared with group 2 patients, the patients with office hypertension exhibited a rather great rise in systolic BP (on the average by 14 and 3 mm Hg, respectively) in response to emotional stress, no increase in reactive anxiety during emotional stress, a higher inadequacy frequency (69,2%) and instability (46,1%) of the level of claims, and behavioral peculiarities (a smaller number of gestures and postures, as well as greater mimics) as compared with patients in whom BP was the same or lower on a working day than on a day-off

The aim of the study was to evaluate the impact of antihypertensive therapy with slow calcium-channel blockers, angiotensin-converting enzyme (ACE) inhibitors, and ß-adrenergic receptor blockers on the metabolism and blood levels of major adrenal androgens and gonads, as well as the insulin resistance in males with arterial hypertension (AH) Ninety-one patients with AH and 15 age-matched healthy male controls were examined The hypertensive males treated with slow calcium-channel blockers or ACE inhibitors were found to have a lower level of insulin and higher levels of dehydroepiandrosterone sulfate and free testosterone on the 30th day of treatment Those on blockers were observed to have a higher level of insulin and lower levels of major adrenal and testicular androgens as compared with their baseline levels Therapy did not alter the levels of gonadotropic hormones, estradiol, and cortisol and they did not differ in the compared groups The family history of AH has a modulating effect on a hormonal response in males with AH treated with antihypertensive agents

To study the pharmacoepidemiology of hypertensive disease (HD) in the Ulyanovsk Region, as well as its conformity to the present state-of-the-art, prescriptions were analyzed by examining the outpatient medical records of hypertensive patients treated in different therapeutic-and-prophylactic institutions of Ulyanovsk and its Region. A total of 681 outpatient medical records were analyzed. The treatment of hypertensive patients in the Ulyanovsk Region is up to the present-day recommendations. The basic classes of antihypertensive agents prescribed by the physicians of the Ulyanovsk Region were angiotensin-converting enzyme inhibitors used in 84,6% of the cases, diuretics in 66.1%, calcium antagonists and ß-adrenoblockers in 28,2 and 27,8%, respectively. In the Ulyanovsk Region, the proportion of long-acting antihypertensive agents prescribed to patients with HD was found to remain low as compared with the results of the PIFAGOR study, which is mainly accounted for by economical causes.

To compare blood pressure (BP) variability and the basic parameters of hemodynamics, the extent of an atherosclerotic process in the carotid arteries in patients aged 65 years or more who had uncomplicated systolic-and-diastolic and isolated systolic arterial hypertension (AH), 201 patients aged 65-88 years who had (mean AH duration, 12 44±0 64 years) was examined A rise was found in systolic and diastolic BP variability irrespective of the mode of BP elevation There was a predominance of external and common carotid arterial stenosis in hypertensives as compared with control normotensives (χ²=8,10,p<0,01 and x²=5,2,p<0,05, respectively), impaired carotid hemodynamics described by the labored perfusion pattern (increased vascular resistance indices with decreased linear blood flow velocities) in the presence of lower arterial elastic and tonic properties A positive correlation was observed between the number of affected arteries and systolic BP variability during day-light hours (r=0,26,p<0,05) In addition, the latter had a negative correlation with linear blood flow velocities in the common carotids during the whole day and day-light hours (r=-0,33-0,34,p<0,01 and r=-0,25-0,26,p<0,05, respectively) The increased systolic BP variability is due to atherosclerotic lesions of mainly the common carotid arteries with altered baroreflex sensitivity

Patients’ responses, mainly a high anxiety, have a great impact on the development of arterial hypertension (AH) and its complications The capacities of the current projective procedure - psychogeometnc testing - to identify psychoemotional disorders in young patients with AH in relation to the severity of disease had not been studied, which was the purpose of the present study The psychogeometnc test was used to examine 138 persons, including 95 young patients with AH, who presented all three degrees of the severity of disease, and 43 control persons who were clinically healthy The patients with AH of varying severity were found to be psychologically heterogeneous in all three subgroups, there were contradictory intrapersonal trends that might lead to the formation of an intrapsychic conflict and increase the level of their anxiety This assumes a differential approach to psychologically correcting the psychoemotional disorders detected in young patients with AH of various severity

The study was undertaken to evaluate autonomic cardiac rhythm regulation in patients with hypertensive disease (HD) in the presence and absence of late ventricular potentials (LVPs) Eighty five hypertensive patients aged 30 to 73 years (mean age 54±9 years) were examined In all the patients, LVPs were recorded by signal-averaged ECG and cardiac rhythm variability was analyzed This study revealed that in a group of HD patients with detected LVPs, cardiac rhythm variability was less than that in those without LVPs The HD patients with detected LVPs showed an increase in their sympathetic impact on cardiac rhythm regulation, as manifested by significantly higher LF/HF ratios (1,85±0,21 and 1,15±0,15, respectively,p<0,05) than did the patients without LVPs This is also confirmed by a moderate positive correlation between LF/HF and TotalQRS r=0,43,p=0,0001

Three hundred and eighty children and adolescents (286 boys and 102 girls) aged 7 to 18 years who had elevated blood pressuie (BP) - BP elevation being recorded at least 3 times on individual visits to a doctor - were examined 24-hour BP monitoring was made in all the examinees to confirm the presence of arterial hypertension (AH) and to specify its grade Analyzing the find mgs indicated that in 24% of the examinees, BP values were in the normal range (daily pressure load was less than 25%), 43% of the patients were found to have labile AH (daily pressure load was within 25-50%), stable hypertension (daily pressure load was more than 50%) was recorded in 33% The predominant form of arterial hypertension m children with stable AH (daily pressure load was more than 50%) was a steady-state increase in systolic BP Reduced nocturnal BP dipping was observed in 29% of all the examinees The study of BP variability indicated a significant increase in this parameter depending on the degree of hypertension burden Thus, the findings suggest that the examinees had increased vascular tonicity and the impairments associated with the development of cardiovascular events m adulthood