Impact of antihypertensive therapy on the functional state of the pituitary-gonadal system in patients with arterial hypertension
https://doi.org/10.18705/1607-419X-2005-11-1-34-38
Abstract
The aim of the study was to evaluate the impact of antihypertensive therapy with slow calcium-channel blockers, angiotensin-converting enzyme (ACE) inhibitors, and ß-adrenergic receptor blockers on the metabolism and blood levels of major adrenal androgens and gonads, as well as the insulin resistance in males with arterial hypertension (AH) Ninety-one patients with AH and 15 age-matched healthy male controls were examined The hypertensive males treated with slow calcium-channel blockers or ACE inhibitors were found to have a lower level of insulin and higher levels of dehydroepiandrosterone sulfate and free testosterone on the 30th day of treatment Those on blockers were observed to have a higher level of insulin and lower levels of major adrenal and testicular androgens as compared with their baseline levels Therapy did not alter the levels of gonadotropic hormones, estradiol, and cortisol and they did not differ in the compared groups The family history of AH has a modulating effect on a hormonal response in males with AH treated with antihypertensive agents
About the Author
N. V. Ivanov
Санкт-Петербургская медицинская академия последипломного образования
Russian Federation
Russian Federation
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Review
For citations:
Ivanov N.V. Impact of antihypertensive therapy on the functional state of the pituitary-gonadal system in patients with arterial hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2005;11(1):34-38. (In Russ.) https://doi.org/10.18705/1607-419X-2005-11-1-34-38
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