Comparative efficacy Noliprel forte and Ko-renitec at high risk arterial hypertension patients
https://doi.org/10.18705/1607-419X-2006-12-1-56-58
Abstract
The aim of the study was to compare i he clinical efficacy and tolerance of fixed combinations of angiotensin-converting enzyme (ACE) and diuretic noliprel and co-renitec in patients with mild and moderate arterial hypertension with high risk of cardiovascular events. All investigated patients didn't achieved normal AP level with monotherapy. The study was blinded, randomised and performed in parallel groups (20 subjects in each group). The clinical effects were evaluated after 6 months of therapy by 1 tablet of noliprel-forte (4 mg / 12.5 mg) or co-renitec (20 mg / 12.5 mg). The antihypertensive effect was comparable for both dings, but fixed combination of noliprel-forte show advantage in reducing of LV hypertrophy and improvement of arterial elasticity.
About the Authors
S. Nedogoda
Волгоградский государственный медицинский университет
Russian Federation
Russian Federation
T. Chalyabi
Волгоградский государственный медицинский университет
Russian Federation
Russian Federation
V. Tioina
Волгоградский государственный медицинский университет
Russian Federation
Russian Federation
Y. Brel
Волгоградский государственный медицинский университет
Russian Federation
Russian Federation
E. Prokhorova
Волгоградский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Рекомендации по профилактике, диагностике и лечению артериальной гипертензии. Артер. гипертен. '2001; 7 (1): (Приложение).
2. Castaigne A., Chaimers J., Morgan T. et al. Efficacy and safety оf an oral fixed low-dose perindopril 2 mg, indapamid 0,625 mg combination: a randomized, double blind, placebo- controlled study in elderly patients with mild-in moderate hypertension. Clin Exper Hypertens 1999; 21 (7): 1097-110.
3. Сhalmars J., Castaigne A., Morgan T., Chastang C. Long term efficacу of a new fixed very low dose angiotensin converting enzyme inhibitor/diuretic combination as first line therapy in elderly hypertensive patients. J Hypertens 2000; 18: 327-37.
4. Chanudet X., Phong Chan N., De Champvallins M. Very-low-dose perindopril 2mg/ indapamide 0,625 mg combination gives higher response and normalization rates than losartan 50 mg in the treatment of essential hypertension. Am J Hypertension 2000; 4: 140.
5. Joint National Committee on Prevention, Detection. Evaluation, and Treatment of High Blood Pressure. The Seventh Report oj the Joint National Commitee on Prevention. Detection. Evaluation, and Treatment of High Blood Pressure (JNC-VII). JAMA May 21, 2003; 289 (19):
6. De Luca N., Safar M.E. Efficacy of a very-low-dose perindopril 2 mg/indapamide 0,625 mg on cardiac hypertrophy in hypertensive patients. J Hypertens 2002; 20 (4).
7. European Society of Hypertension European Society of Cardiology, Guidelines for the management of arterial Hypertension. Guidelines Committee. J of Hypertension 2003; 21: 1011-53.
8. Hansson L., Zanchetti A., Carruthers S.G. et al. Effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial. Lancet 1998; 351: 1755-62.
9. Jaillon P. Efficacy and safety of PRETERAX 4/125 in the second-line treatment with perindopril 4 mg: comparison versus per 4 mg (looking for different in efficacy) and per 8 mg (looking for equivalent efficacy) Expert report; 29 May 1996.
10. Joint National Committee on Prevention. Detection, Evaluation, and Treatment of High Blood Pressure. The Seventh Report of the Joint National Commitee on Prevention. Detection. Evaluation, and Treatment of High Blood Pressure (JNC- VII) JAMA May 21; 2003; 289 (19).
11. Luccioni R., Sever P.S., Perri T. An equivalence study of the safety and efficacy of a fixed-dose combination of perindopril with indapamide versus fixed-dose combinations of captopril with hydrochlorothiazide and enalapril with hydrochlorothiazide in the treatment of hypertension. J Hypertens. 1995 13 (12 Pi 2): 1847-51.
12. Mogensen C.E., Viherti C., Halimi S. et al. Treatment based on line dose combination of perindopril and indapamide reduces albuminuria more effectively than enalapril in hypertensive type 2 diabetic patients. Am J Hypertens 2002: 15: 21A-22A.
13. Safar M. Perindopril and indapamide as a combination in treatment of mild to moderate hypertension. J Hypertens 1994; 7 (4): 43A.
Review
For citations:
Nedogoda S., Chalyabi T., Tioina V., Brel Y., Prokhorova E. Comparative efficacy Noliprel forte and Ko-renitec at high risk arterial hypertension patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2006;12(1):56-58. (In Russ.) https://doi.org/10.18705/1607-419X-2006-12-1-56-58
Views:
1619
Email this article 