Activation of the central alpha2 - adrenoceptors in pre- and early postnatal periods as a possible way of arterial hypertension correction
https://doi.org/10.18705/1607-419X-2007-13-2-172-176
Abstract
The central alpha2 - adrenoceptors in SHR rats in pre- and early postnatal periods were activated to study evolution of arterial hypertension in offsprings. It is demonstrated that the injection of guanfacine to female from 10th to 18th days of pregnancy or since 2nd to 15th days after delivery reduce the blood pressure level in the posterity after their achievement of puberty. This effect is less significant in male offsprings. It is suggested that the less effect in male-offsprings is conditioned by the different density of adrenoceptors which dehends on androgene hormones.
About the Authors
R. S. Chrustaleva
Almazov Federal Center of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
N. A. Feldsherova
Almazov Federal Center of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
V. A. Tsyrlin
Almazov Federal Center of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
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Review
For citations:
Chrustaleva R.S., Feldsherova N.A., Tsyrlin V.A. Activation of the central alpha2 - adrenoceptors in pre- and early postnatal periods as a possible way of arterial hypertension correction. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2007;13(2):172-176. (In Russ.) https://doi.org/10.18705/1607-419X-2007-13-2-172-176
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