The captopril and eprosartan influence on hemodynamic parameters in rats with renovascular hypertension
https://doi.org/10.18705/1607-419X-2007-13-4-242-245
Abstract
The aim of this investigation is the comparison of captopril and eprosartane influence on the level blood pressure, its variability and baroreceptor reflex in normal rats and rats with vasorenal hypertension.
It was shown that hypertensive rats had higher level of blood pressure, heart rate and its variability than normotensive rats. There was no relationship between arterial blood pressure and its variability in normal as well as hypertensive rats.
Captopril decreased blood pressure and had no effect on variability of blood pressure. In rats with renovascular hypertension an increased baroreflex and decreased variability of heart rate was note.
Eprosartan, as well as captopril, decreased blood pressure, but increased variability of blood pressure in rats with hypertension.
It was shown that hypertensive rats had higher level of blood pressure, heart rate and its variability than normotensive rats. There was no relationship between arterial blood pressure and its variability in normal as well as hypertensive rats.
Captopril decreased blood pressure and had no effect on variability of blood pressure. In rats with renovascular hypertension an increased baroreflex and decreased variability of heart rate was note.
Eprosartan, as well as captopril, decreased blood pressure, but increased variability of blood pressure in rats with hypertension.
About the Authors
K. E. Gavrikov
Almazov Federal Centre of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
N. S. Rubanova
Almazov Federal Centre of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
R. S. Chrustaleva
Almazov Federal Centre of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
V. A. Tsyrlin
Almazov Federal Centre of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
References
1. Гавриков К.Е., Галустьян Г.Э., Цырлин В.А. Зависимость между барорецепторным рефлексом и вариабельностью артериального давления и периода сокращений сердца у крыс при артериальной гипертензии. Бюлл.экспер.биол.т мед., 1995, 119,5-7.
2.
3. Галустьян Г.Э., Гавриков К.Е. Характеристика вариабельности артериального давления у человека и животных. Успехи физиол.наук, 1999,30,4,67-80.
4.
5. Floras J.S., Hassan M.O., Jones J.V., Osikowska B.A., Sever P.S., Sleight P. Factors influencing blood pressure and heart rate variability in hypertensive humans. Hypertension, 1988, 11(3), 273-281.
6.
7. Helmchen U., Kneissler U., Liard J.F., Peters G. Renin secretion in the earliest stage of Goldblatt-type hypertension in rats. Klin Wochenschr., 1972, 50(17), 841-844.
8.
9. Mancia G. Related Articles, Links Methods for assessing blood pressure values in humans. Hypertension, 1983, 5 (5 Pt 2), 1115-13.
10.
11. Mancia G, Giannattasio C, Parati G, Failla M, Stella ML. [Hemodynamics and pressure variability in isolated systolic hypertension.Cardiologia. 1994, 39(12 Suppl l), 247-250.
12.
13. Parati G., Castiglioni P., Di Rienzo M., Omboni S., Pedotti A., Mancia G. Sequential spectral analysis of 24-hour blood pressure and pulse interval in humans. Hypertension, 1990, 16(4), 414-421.
14.
15. Regoli D., Hess R., Brunner H., Peters G., Gross F. Interrelationship of renin content in kidneys and blood pressure in renal hypertensive rats. Arch Int Pharmacodyn Ther., 1962, 140,416-426.
16.
17. Smyth H.S., Sleight P.S., Pickering G.W. Reflex regulation of arterial pressure during sleep in man. Circulat. Res.,1969,1969,24,109-121.
18.
Review
For citations:
Gavrikov K.E., Rubanova N.S., Chrustaleva R.S., Tsyrlin V.A. The captopril and eprosartan influence on hemodynamic parameters in rats with renovascular hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2007;13(4):242-245. (In Russ.) https://doi.org/10.18705/1607-419X-2007-13-4-242-245
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