Side effects of angiotensin-converting enzyme inhibitors in hypertensive patients
https://doi.org/10.18705/1607-419X-2010-16-4-412-417
Abstract
Objective. To evaluate the side effects (SE) of angiotensin-converting enzyme inhibitors (ACEI) in hypertensive patients in real practice in Russia in a study based on pharmacoepidemiologic design. Design and methods. Under 337 reports of SE there were 162 on ACEI. Mean value of SE for 1 patient was 2,83; mean value of class-specific SE - 1,17. The disorders of respiratory tract (68 % patients), central nervous system (51,2 %) and skin (21 %) were predominant; the most frequent SE were cough, hemodynamic SE (headache, dizziness, weakness), skin allergic SE. There was gender difference in frequency of cough, but no difference was found in the structure of SE among young and elderly patients. The most serious SE were observed in obese patients (body mass index > 30 m2). 6,2 % patients needed hospitalization. More than 80 % drugs were ACEI generics that characterizes their safety.
About the Authors
M. Leonova
Russian state medical university
Russian Federation
Russian Federation
D. Belousov
Russian Society of Clinical Investigetors
Russian Federation
Russian Federation
A. Galitskiy
Russian state medical university
Russian Federation
Russian Federation
V. Amagzaeva
Russian state medical university
Russian Federation
Russian Federation
N. Burdelova
Russian state medical university
Russian Federation
Russian Federation
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Review
For citations:
Leonova M., Belousov D., Galitskiy A., Amagzaeva V., Burdelova N. Side effects of angiotensin-converting enzyme inhibitors in hypertensive patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(4):412-417. (In Russ.) https://doi.org/10.18705/1607-419X-2010-16-4-412-417
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