Possibility of lipid metabolism correction by angiotensin converting enzyme inhibitors in clinical practice

Abstract

Objective. To assess the efficiency of perindopril (Prestarium A) 10 mg daily in hypertensive patients with dyslipidemia. Design and methods. 276 medical doctors (physicians and cardiologists) took part in the study. 2075 patients aged 18-67 years old with 1-3 degree arterial hypertension were included (mean age 55.4 ± 8.1 years). Perindopril 10 mg daily (in the morning) was prescribed to all patients. In case the patients were taking blockers of renin-angiotensin-aldosterone system, the drugs were withdrawn, while therapy by the antihypertensive drugs of other classes was continued if necessary. Antiaggregants were taken by 17 % of subjects, anti-inflammatory drugs — by 11 %, statins — by 23.2 %, and the target lipid levels were not achieved. Results. After 4 months of therapy by Perindorpil 10 mg daily more than 90 % of patients achieved target blood pressure, and blood pressure was lower than 140/90 mm Hg in 100 %. The change for Perindopril led to the decrease of systolic and diastolic blood pressure for 21 и 17.1 %, respectively (p < 0.05). Improvement of lipid profile was observed: total cholesterol level decreased for 15 %, and level of low density lipoproteins — for 16.3 %, while high density lipoproteins increased for 9.5 % (p < 0.05). Conclusion. At real clinical practice Perindopril 10 mg/day effectively decreases total cholesterol, low density lipids and increases high density lipids in patients with arterial hypertension and high lipids. Moreover, 90 % of patients achieved target blood pressure.