Endothelial dysfunction in patients with bronchial asthma and concomitant essential hypertension
https://doi.org/10.18705/1607-419X-2012-18-1-52-57
Abstract
Objective. To investigate endothelial function in asthmatic subjects including patients with essential hypertension (EH). Design and methods. The levels of endothelium-dependent and endothelium-independent vasodilation, pulmonary artery systolic pressure (PASP) were evaluated by ultrasound scanner before and after the treatment of the asthma exacerbation. Results. The PASP values before treatment in patients with asthma and concomitant EH (31.3 ± 0.6 mm Hg) and II stage (31.4 ± 0.7 mm Hg) were higher, than in patients with normal blood pressure (28.3 ± 0.6 mm Hg), p < 0.05. The levels of endothelium-dependent vasodilation after treatment in patients with asthma and concomitant EH I stage (11.12 ± 1.00 %) and II stage (10.04 ± 0.88 %) were lower, than in patients with normal blood pressure (15.60 ± 1.58 %), p < 0.05. The levels of endothelium-dependent and endothelium-independent vasodilation, PASP were comparable in patients with different asthma severity. Conclusion. Endothelial function, PASP in asthmatic subjects are related to the presence of concomitant EH.
About the Authors
A. G. Kozyrev
Scientific Research Institution of Pulmonology at Pavlov St Petersburg State Medical University
Russian Federation
Russian Federation
A. Y. Gichkin
Scientific Research Institution of Pulmonology at Pavlov St Petersburg State Medical University
Russian Federation
Russian Federation
V. E. Perley
Scientific Research Institution of Pulmonology at Pavlov St Petersburg State Medical University
Russian Federation
Russian Federation
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For citations:
Kozyrev A.G., Gichkin A.Y., Perley V.E. Endothelial dysfunction in patients with bronchial asthma and concomitant essential hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2012;18(1):52-57. (In Russ.) https://doi.org/10.18705/1607-419X-2012-18-1-52-57
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