Association of blood pressure and coronary heart disease in women of an open population of a moderately urbanized city of Western Siberia

Objective. The aim of this study was to assess the association between the level of blood pressure (BP) and the prevalence of coronary heart disease (CHD) in women of working age in an open population of a moderately urbanized Siberian city (on the model of Tyumen).

Design and methods. We included 1000 women of an open urban population aged 25–64 years, 250 people in each of four decades of life (among persons 25–34, 35–44, 45–54, 55–-64 years old), selected by the method of a random representative sample from the electoral lists of the administrative district of Tyumen, the response was 70,3% (703 participants). In all subjects we measured BP; assessed the presence of coronary artery disease — according to standardized epidemiological methods: based on the extended criteria, “definite” CHD (strict criteria) and “possible” CHD (non-strict criteria) were distinguished. Statistical analysis was performed using STATISTICA 12.0 software, the differences were considered significant at p-level ≤ 0,005.

Results. Almost every third woman (25–64 years old) had increased BP (34,7 %), the frequency of increased BP grows with age, reaching 63,3 % in the older group. Low awareness of high BP and low adherence to treatment were found. There was a correlation between the prevalence of CHD and BP level and age. In the presence of increased systolic BP, the chance of developing CHD in women aged 25–64 years in the open population increases by 1,9–2,7 times (p < 0,05), in the presence of increased diastolic BP, the chance of developing CHD according to extended criteria increases by 2,1 times (odds ratio = 2,08, 95 % confidence interval (1,15; 3,74)).

Conclusions. Our results can be used for improving the strategy of primary cardiovascular prevention in preventive programs of the Western Siberia region.

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