Factors associated with the development of arterial hypertension in the 10-year follow-up period in people under 45 years of age
https://doi.org/10.18705/1607-419X-2026-2535
EDN: RJFAYT
Abstract
The aim of the study was to identify factors associated with the development of arterial hypertension (HTN) over a ten-year period, in people under 45 years of age.
Design and methods. The study included residents of Novosibirsk, 25–44 years old, examined in 2013–2016 and in 2023–2024 at the Research Institute of Therapy and Preventive Medicine — 174 people (40,2 % men, 59,8 % women). At the time of examination in 2013– 2016, they did not have an increase in blood pressure. Ten years later, at the examination in 2023–2024, in 51 individuals HTN was diagnosed. This article presents a comparison of two groups of individuals based on the 2013–2016 examination — 123 individuals with normal BP and 51 individuals with HTN developed subsequently (after 10 years).
Results. According to the results of multivariate logistic regression analysis, the development of HTN in individuals under 45 years of age during the remote 10-year period was directly associated with systolic blood pressure level (odds ratio (OR) = 1,054, 95 % confidence interval (CI) (1,009–1,101), p = 0,019) and age (OR = 1,124, 95 % CI (1,029–1,228), p = 0,009), independent of sex, alcohol consumption, waist circumference and lipid levels.
Conclusion. In summary, in young adults under 45 years of age, the chance of developing HTN in the distant 10-year period increases by 5,4 % with each 1-mmHg increase in systolic blood pressure and by 2,4 % with each 1-year increase in age.
Supporting agencies: The work was performed within the framework of the State assignment under the budgetary topic of the research work No. FWNR 2024-0002.
About the Authors
S. R. Ledovskikh
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Sofia R. Ledovskikh, MD, Postgraduate Student, Research Associate, Laboratory of Genetic and Environmental Determinants of the Human Life Cycle
175/1 B. Bogatkova str., Novosibirsk, 630089
L. V. Shcherbakova
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Lilia V. Shcherbakova, MD, Senior Researcher, Laboratory of Clinical and Population and Preventive Studies of Therapeutic and Endocrine Diseases
Novosibirsk
D. V. Denisova
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Diana V. Denisova, MD, PhD, DSc, Leading Researcher, Laboratory of Preventive Medicine
Novosibirsk
V. S. Shramko
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Victoria S. Shramko, MD, PhD, Research Associate, Laboratory of Clinical, Biochemical, Hormonal Studies of Therapeutic Diseases
Novosibirsk
O. V. Pushkina
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Olga V. Pushkina, MD, Doctor of Clinical Laboratory Diagnostics, Laboratory of Clinical, Biochemical, Hormonal Studies of Therapeutic Diseases
Novosibirsk
Yu. I. Ragino
Research Institute of Therapy and Preventive Medicine
Russian Federation
Russian Federation
Yulia I. Ragino, MD, PhD, DSc, Corresponding Member of the Russian Academy of Sciences, Professor, Head
Novosibirsk
References
1. Zayats AN, Shishko VI. Prediction of the development of arterial hypertension in young men with high normal blood pressure. Journal of GrSMU. 2023;(6):569–574. (In Russ.) https://doi.org/10.25298/2221-8785-2023-21-6-569-574
2. Liu J, Bu X, Wei L, Wang X, Lai L, Dong C, Ma A, et al. Global burden of cardiovascular diseases attributable to hypertension in young adults from 1990 to 2019. J Hypertens. 2021;39(12):2488–2496. https://doi.org/10.1097/HJH.0000000000002958
3. Yarmukhamedova DZ, Nuritdinova NB, Shoalimova ZM, Makhmudova MS, Ibragimov ZS. Prevalence of arterial hypertension and risk factors in young adults. Science, Technology and Education. 2021;3(78):60–63. (In Russ.)
4. Meher M, Pradhan S, Pradhan SR. Risk factors associated with hypertension in young adults: a systematic review. Cureus. 2023;15(4):e37467. https://doi.org/10.7759/cureus.37467
5. Chiang PP, Lamoureux EL, Shankar A, Tai ES, Wong TY, Sabanayagam C. Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease. BMC Public Health. 2013;13:730. https://doi.org/10.1186/1471-2458-13-730
6. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111–188. https://doi.org/10.1093/eurheartj/ehz455
7. Abidova DE, Mukhamedova MG. The importance of screening for arterial hypertension in young women. Cardiology in Belarus. 2025;17(1):36–53. (In Russ.) https://doi.org/10.34883/PI.2025.17.1.003
8. Karamnova NS, Rytova AI, Shvabskaya OB, Makarova YK, Maksimov SA, Balanova YuA, et al. Association of dietary habits and alcohol consumption with heart disease dietary habits and alcohol consumption with cardiovascular diseases and diabetes mellitus in the adult population. Diabetes mellitus in the adult population. Results of the epidemiologic study ESSE-RF. Cardiovascular Therapeutics and Prevention. 2021;20(5):2982. (In Russ.) https://doi.org/10.15829/1728-8800-2021-2982
9. Sabirov IS, Murkamilov IT, Fomin VV, Sabirova AI, Ismarova GS, Yusupov FA. Arterial hypertension in young age: the modern state of the problem. The Scientific Heritage. 2021;72(2):15–23. (In Russ.)
10. Najjar SS, Scuteri A, Lakatta EG. Arterial aging: is it an immutable cardiovascular risk factor? Hypertension. 2005;46(3):454–462.
11. Mangileva TA. Comparative characteristics of lifestyle, office and ambulatory blood pressure among students from Tropical Africa, India and Russia. Cardiovascular Therapy and Prevention. 2023;22(10):3700. (In Russ.) https://doi.org/10.15829/1728-8800-2023-3700
12. Hong K, Yu ES, Chun BC. Risk factors of the progression to hypertension and characteristics of natural history during progression: a national cohort study. PLoS One. 2020;15(3):e0230538. https://doi.org/10.1371/journal.pone.0230538
13. Pastukhov AV, Cherkashin DV, Solntsev VN, Alanichev AE, Makiev RG, Shakhnovich PG, et al. Peculiarities of arterial hypertension in males in different age ranges. Arterial’naya Gipertenziya = Arterial Hypertension. 2014;20(4):296–306. (In Russ.) https://doi.org/10.18705/1607-419X-2014-20-4-296-306
14. Manfredini R, De Giorgi A, Tiseo R, Boari B, Cappadona R, Salmi R, et al. Marital status, cardiovascular diseases, and cardiovascular risk factors: a review of the evidence. J Womens Health (Larchmt). 2017;26(6):624–632. https://doi.org/10.1089/jwh.2016.6103
15. Tsygankova DP, Fedorova NV. Separate socioeconomic aspects of arterial hypertension risk. Arterial’naya Gipertenziya = Arterial Hypertension. 2020;26(2):155–162. (In Russ.) https://doi.org/10.18705/1607-419X-2020-26-2-155-162
Review
For citations:
Ledovskikh S.R., Shcherbakova L.V., Denisova D.V., Shramko V.S., Pushkina O.V., Ragino Yu.I. Factors associated with the development of arterial hypertension in the 10-year follow-up period in people under 45 years of age. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2026;32(1):97-106. (In Russ.) https://doi.org/10.18705/1607-419X-2026-2535. EDN: RJFAYT
Views:
68
JATS XML
Email this article 