Beta-adrenoreceptor gene polymorphisms and the risk of essential hypertension
https://doi.org/10.18705/1607-419X-2015-21-3-259-266
Abstract
The aim of the current study was to analyse an association between ADRB1, ADRB2 и ADRB3 gene variants and essential hypertension (EH) in the ethnic group of Tatars residing in the Republic of Bashkortostan (Russian Federation).
Design and methods. We performed genotyping of ADRB1 rs1801252, ADRB2 rs1042713 and ADRB3 rs4994 polymorphisms using polymerase-chain reaction with allele-specific primers in the study group consisting of 530 individuals (216 hypertensive patients, 314 controls). Considering the fact that gender is a major risk factor for the development of hypertension before age 45, the study group was composed of male individuals.
Results. We detected an association between ADRB2 rs1042713 and EH. ADRB2*A/G genotype was found to be associated with an increased risk of EH (odds ratio, OR = 1,68; p = 0,004); ADRB2*G/G genotype, on the contrary, was shown to be protective against the disease (OR = 0,58; p = 0,01). ADRB2*A/G genotype also marked an increased risk of hypertension in patients with obesity (OR = 3,01; P = 0,01), while ADRB2*G/G genotype carriers with body mass index > 30 kg/m 2 had lower risk of EH (OR = 0,29; P = 0,01) when compared to the control individuals of the same category.
Conclusion. Our study has shown that ADRB2 rs1042713 polymorphism is associated with the risk of EH, and the effect is more pronounced in individuals with obesity.
About the Authors
Y. R. Timasheva
Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia 71 Oktyabrya av., 450054 Tel.: +7(347)235–60–88. Fax: +7(347)235–60–88
Russian Federation
Russian Federation
MD, PhD, Researcher, Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa,
Russia
T. R. Nasibullin
Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia 71 Oktyabrya av., 450054 Tel.: +7(347)235–60–88. Fax: +7(347)235–60–88
Russian Federation
Russian Federation
MD, PhD, Senior Researcher, Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia
E. B. Imaeva
Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia 71 Oktyabrya av., 450054 Tel.: +7(347)235–60–88. Fax: +7(347)235–60–88
Russian Federation
Russian Federation
MD, PhD student, Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia
G. Kh. Mirsaeva
Bashkir State Medical University, Ufa, Russia
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Head, Department of Internal Diseases, Bashkir State Medical University, Ufa, Russia
O. E. Mustafina
Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia 71 Oktyabrya av., 450054 Tel.: +7(347)235–60–88. Fax: +7(347)235–60–88
Russian Federation
Russian Federation
PhD, Doctor of Biology Science, Professor, Head, Laboratory of Physiology Genetics, Institute of Biochemistry and Genetics, Ufa Scientific Centre of Russian Academy of Sciences, Ufa, Russia
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Review
For citations:
Timasheva Y.R., Nasibullin T.R., Imaeva E.B., Mirsaeva G.Kh., Mustafina O.E. Beta-adrenoreceptor gene polymorphisms and the risk of essential hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(3):259-266. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-3-259-266
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