Valsartan and other ATj-angiotensive receptor blockers: the specific features of clinical pharmacology and some experience in using them to treat arterial hypertension

Abstract

The paper considers the clinical pharmacology, mechanism of action, efficacy, and safety of AT₁-angiotensivе receptor blockers. Some studies have indicated that A AT₁-angiotensivе receptor blockers may prevent the development of cerebral stroke, diabetes mellitus in the treatment of arterial hypertension in patients at high risk for these diseases. By taking into account the unique spectrum of their pharmacological effects and excellent tolerability AT₁-angiotensivе receptor blockers may be used in therapy of arterial hypertension of a great variety, irrespective of sex, age, race, comorbidity.