Role of nitric oxide and its metabolites in the regulation of vascular tone in hypertensive disease
https://doi.org/10.18705/1607-419X-2003-9-6-202-204
Abstract
The effects of nitric oxide and its metabolites on vascular tone were studied in patients with hypertensive disease (HD) during isometric exercise and reactive hyperemia tests. During the static loading tests, blood pressure increases were followed by the development of vasospastic reactions, by the higher activity of the sympathetic part of the autonomic nervous system, by a reduction in parasympathetic effects, by a decrease in the activity of superoxide dismutase and in the concentrations of nitrites/nitrates in the plasma, by the activation of lipid peroxidation, and by an increase in the levels of S-nitrosothiols. The reactive hyperemia test showed a higher production of nitric oxide and developed vasodilator reactions. The activation of lipid peroxidation is common to these stress tests. However, the formation of peroxynitrites and S-nitrosothiols aggravates nitric oxide deficiency and potentiates the development of vasoconstrictive reactions in patients with HD under decreased SOD-like activity.
About the Authors
O. M. Moiseyeva
ФГБУ «ФЦСКЭ им. В.А. Алмазова» Минздрава России
Russian Federation
Russian Federation
L. A. Aleksandrova
Государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
I. V. Yemelyanov
ФГБУ «ФЦСКЭ им. В.А. Алмазова» Минздрава России
Russian Federation
Russian Federation
Y. I. Merkulova
НИИ кардиологии им. В.А. Алмазова Минздрава РФ
Russian Federation
Russian Federation
T. G. Ivanova
ФГБУ «ФЦСКЭ им. В.А. Алмазова» Минздрава России
Russian Federation
Russian Federation
A. A. Zhloba
НИИ кардиологии им. В.А. Алмазова Минздрава РФ
Russian Federation
Russian Federation
References
1. Vanhoutte P.M. Endothelial dysfunction in hypertension. J Hypertens Suppl. 1996; 14 (5); S83 - S93.
2. Celermajer D.S., Sorensen K.B., Gooch V.M. el al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111 - 5.
3. Barenbrock M., Hausberg M., Kosch M. el al. Flow-mediated vasodilation and distensibilily in relation to intima-media thickness of large arteries in mild essential hypertension. Am J Hypertens 1999; 12 (IO Pt 1): 973 - 9.
4. Monobe H., Yamanari H., Nakamura K, Ohe T. Effects of tow-dose aspirin on endothelial function in hypertensive patients. Clin Cardiol 2001; 24 (11): 705 - 9.
5. Иванова O.B. Балахонова Т.В., Соболева Г.Н. и др. Состояние зпдо-телийзависимой вазодилатации плечевой артерии у больных гипертонической болезнью, оцениваемое с помощью ультразвука высокого разрешении. Кардиология 1997; 37 (7): 41 - 5.
6. Weberr R. Stergiopulos N., Brunner H.R. Hayoz D. Contributions of vascular tone and structure to elastic properties of amedium-sized artery. Hypertension 1996: 27: 816 - 22.
7. Node K., Kilakaze M., Yoshikawa H. Reduced Plasma Concentrations of Nitrogen Oxide in Individuals With Essential Hypertension. Hypertension, 1997; 30 (3 Ptl): 405 - 8.
8. Camilletti A., Moretti N. Giacchetti G. el al. Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients. Am J Hypertens 2001; 14 (4 Pt I): 382-6.
9. Pierdomenico S.D., Cipollone F., Lapenna D. el al. Endothelial function in sustained and white coal hypertension. Am J Hypiertens. 2002 Nov: 15 (11): 946-52.
10. Murakami E., Matsuzaki K., Sumimoto T. let al. Clinical significance of pressor responses to laboratory stressor testing in hypertension. Hypertens Res 1996; 19 (2): 133-7.
11. Рекомендации по профилактике, диагностике и лечению артериальной гипертензии. Рекомендации экспертов Всероссийского общества кардиологов (ИНОК). 2001.
12. Селютина С.Н., Селютии А.Ю., Паль А.И. Модификации определения концентрации ТБК-активных продуктов сыворотки крови. Клин. лаб. Диагностика 2000; 2: 8-11.
13. Костюк В.A., Потапович А.Л., Ковалева Ж.В. Простой и чувствительный метод определения активности супероксиддисмутазы, основанный на реакции окисления кверцетина. Вопр. мед. хим, 1990; 36 (2): 88 - 91.
14. Guevara I., Iwanejko J., Dembinska-Kiec A. el al. Determination of nitrite/nitrate in human biological material by the simple Criess reaction. Clin Chim Acta 1998 Jun 22; 274 (2): 177 - 88.
15. Ванин А.Ф. Динитрозильные комплексы железа и S-нитрозотиолы - две возможные формы стабилизации и транспорта оксида азота в биосистемах. Биохимия 1998; 63 (7): 924 - 38.
16. Jourd'beuil D., Hallen K., Feelisch M. Crisham М.B. Dynamic state of S-nitrosothiols in human plasma and whole blood. Free Radic Biol Med. 2000; 28 (3): 409-17.
17. Eiserich J.P. Patel R.P., O'Donnell V.B. Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules. Mol Aspects Med 1998; 19 (4-5): 221 - 357.
18. Channon KM., Qian H., George S.E. Nitric oxide syntbase in atherosclerosis and vascular injury. Arterioscler Thromb Vase Biol. 2000; 20 (8): 1873 - 81.
19. Hoffmann J., Haeudelerf J., Zeiber A.M., Dimmeler S. TNF-a and oxlDI reduce protein S-Nitrosylation in endothelial cells. J Biol Chem 2001: 276 (44): 41383 - 7.
20. Borutaite V., Mutthias A., Harris H. et al. Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation. Am J Physiol Heart Circ Physiol 2001: 281 (6): H2256-H2260.
21. Patel K.P., Li Y., Hirooka V. Role of nilric oxide in central sympathetic outflow. Experim Biol Med 2001; 226: 814 - 24.
Review
For citations:
Moiseyeva O.M., Aleksandrova L.A., Yemelyanov I.V., Merkulova Y.I., Ivanova T.G., Zhloba A.A. Role of nitric oxide and its metabolites in the regulation of vascular tone in hypertensive disease. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2003;9(6):202-204. (In Russ.) https://doi.org/10.18705/1607-419X-2003-9-6-202-204
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