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"Arterial’naya Gipertenziya" ("Arterial Hypertension")

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Comparison of efficacy of fixed combinations of verapamil SR+ trandolapril and captopril + HCTZ in high risk hypertensive patients

https://doi.org/10.18705/1607-419X-2007-13-2-141-144

Abstract

The blinded randomized study the clinical effecacy and tolerability during 6 month therapy with one of two fixed combinations Tarka (verapamil SR+trandolapril) and Capozide (captopril+HCTZ) were compared patients (20 patients at every group) with arterial hypertension who did not achiev target blood pressure on monotherapy. Tarka was more effective decreased of left ventricular hypertrophy and improved vascular elasticity. Tarka also had better T/P coefficient. Tarka improved glucose level, Capozide worsen potassium levels.

About the Authors

S. V. Nedogoda
Кафедра терапии и семейной медицины ФУВа, Волгоградский государственный медицинский университет
Russian Federation


Т. A. Chalabi
Кафедра терапии и семейной медицины ФУВа, Волгоградский государственный медицинский университет
Russian Federation


V. V. Tsoma
Кафедра терапии и семейной медицины ФУВа, Волгоградский государственный медицинский университет
Russian Federation


U. A. Brel
Кафедра терапии и семейной медицины ФУВа, Волгоградский государственный медицинский университет
Russian Federation


References

1. Рекомендации по профилактике, диагностике и лечению артериальной гипертензии. Артер. гипертен. 2001; 7 (1): (Приложение).

2.

3. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The Seventh Report of the Joint National Commitee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VII). JAMA May 21, 2003; 289 (19):

4.

5. European Society of Cardiology. Guidelines for the management of arterial Hypertension. Guidelines Committee. J of Hypertension 2003; 21: 1011-53.

6.

7. Zillich A.J., Garg J., Basu S., Bakris G.L., et al. Thiazide Diuretics, Potassium, and the Development of Diabetes. A Quantitative Review. Hypertension. 2006;. 48(2):219-224.

8.

9. Luccioni R., Sever P.S., Di Perri T. An equivalence study of the safety and efficacy of a fixed-dose combination of perindopril with indapamide versus fixed-dose combinations of captopril with hydrochlorothiazide and enalapril with hydrochlorothiazide in the treatment of hypertension.J Hypertens. 1995 13(12 Pt 2):1847-51.

10.

11. Dablof B., Sever P.S., Poulter N.R., for the ASCOT investigators. 2005; 366: 895-906.

12.


Review

For citations:


Nedogoda S.V., Chalabi Т.A., Tsoma V.V., Brel U.A. Comparison of efficacy of fixed combinations of verapamil SR+ trandolapril and captopril + HCTZ in high risk hypertensive patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2007;13(2):141-144. (In Russ.) https://doi.org/10.18705/1607-419X-2007-13-2-141-144

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ISSN 1607-419X (Print)
ISSN 2411-8524 (Online)