EVOLUTION OF THE VIEWS ON IMPORTANCE OF BLOOD PRESSURE VARIABILITY
https://doi.org/10.18705/1607-419X-2013-19-1-6-17
Abstract
The phenomenon of variability of blood pressure (BP) has been studied for a long time, but recently, it has made a comeback in scientifi c literature. This is mostly due to the fact that numerous studies have confirmed the importance of BP variability in predicting cardiovascular risk, although the effect of various parameters of variability does not have the same level of cardiovascular risk due to different underlying pathophysiological mechanisms. Interest in BP variability is due to and based on a series of studies carried out by P. Rothwell et al., who analyzed variability in BP in heterogeneous populations. In particular, the analysis of the ASCOT-BPLA trial showed high signifi cance of intervisit variability of ВР and predicted stroke and coronary events. In light ofthese data, the variability of ВР is a promising new target for antihypertensive therapy. A statistically significant decrease of this index indicates the stability of the achieved results following treatment. The most convincing evidence in this respect, are those for the combination of amlodipine and perindopril.
About the Authors
E. A. Troitskaya
Russian People's Friendship University, Moscow
Russian Federation
Russian Federation
Yu. V. Kotovskaya
Russian People's Friendship University, Moscow
Russian Federation
Russian Federation
Corresponding author: Clinical Hospital № 64, the Department of Internal Diseases Propeadeutics at Russian People’s Friendship University, 61 Vavilov st., Moscow, Russia, 117292. E-mail: kotovskaya@bk.ru (Julia V. Kotovskaya, MD, PhD, Professor at the Department of Internal Diseases Propaedeutics at Russian People’s Friendship University).
Zh. D. Kobalava
Russian People's Friendship University, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Troitskaya E.A., Kotovskaya Yu.V., Kobalava Zh.D. EVOLUTION OF THE VIEWS ON IMPORTANCE OF BLOOD PRESSURE VARIABILITY. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2013;19(1):6-17. (In Russ.) https://doi.org/10.18705/1607-419X-2013-19-1-6-17
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