The influence of modification of the glomerular filtration rate on the function of endothelium in patients with chronic kidney disease and arterial hypertension
https://doi.org/10.18705/1607-419X-2008-14-4-356-359
Abstract
Arterial hypertension (AH) is a leading cause of morbidity and mortality of the patients with chronic kidney disease (CKD). The aim of this study was to estimate the function of endothelium in patients with CKD and AH during the period of 12 months. The target blood pressure was achieved in 57 patients initially. Complex examination including biochemical, immune-enzyme analyses and instrumental methods was performed. All patients achieved target blood pressure in 12 months. The glomerular filtration rate (GFR) increased in 55 patients (1st group) from 52,1 ± 2,9 to 70,7 ± 3,5 ml/min (p < 0,01). GFR decreased in 27 patients (2nd group) from 48,9 ± 4,8 to 38,7 ± 4,3 ml/min (p < 0,01). The level of annexin-A5 in patients of 2nd group was more than 3,5 ng/ml. Endothelium-dependent vasodilation improved in patients of 1st group. Endothelium-dependent vasodilation did not change in patients of 2nd group.
About the Authors
I. Yu. Panina
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
A. Sh. Rumyantsev
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
M. A. Menschutina
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
V. V. Achkasova
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
E. V. Schevyakova
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
O. A. Degtereva
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
F. A. Tuguscheva
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
I. M. Zubina
Pavlov State Medical University, St Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Panina I.Yu., Rumyantsev A.Sh., Menschutina M.A., Achkasova V.V., Schevyakova E.V., Degtereva O.A., Tuguscheva F.A., Zubina I.M. The influence of modification of the glomerular filtration rate on the function of endothelium in patients with chronic kidney disease and arterial hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2008;14(4):356-359. (In Russ.) https://doi.org/10.18705/1607-419X-2008-14-4-356-359
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