AORTIC ELASTICITY AND ENDOTHELIUM MOTOVASCULAR FUNCTION IN PRIMARY HYPOTHYROIDISM

Objective. To compare aortic elasticity and vasomotor endothelial function in hypertensive and normotensive patients with decompensated primary hypothyroidism (PHT) and after medical compensation.

 Design and methods. 41 women with PHT were examined, 23 (56 %) subjects had concomitant hypertension. Elasticity of aorta was evaluated by compliance coefficient (CC) and pulse wave velocity (PWV), state of vasomotor endothelial function — by vasodilatation coefficient (VDC). Patients were examined twice: during decompensation and after medical compensation.

Results. Mean values of CC in patients with decompensated PHT were 2,27 (95 % confidence interval 1,53–3,01) and 2,23 (1,78–2,67) mm2/mm Hg in hypertensives and normotensive, respectively, PWV — 12,2 (10,4–13,9) and 12,9 (11,8–14,0) m/s, VDC — 4,51 (2,91–6,11) and 3,72 (2,06–5,37) CU, respectively (all p > 0,05). Compensation of PHT led to the CC increase up to 4,69 (4,13–5,24) and 4,66 (3,96–5,36) mm2/mm Hg, PWV patients till 8,85 (6,77–10,9) and 7,40 (6,68–8,11) m/s, VDC increase up to 10,7 (9,27–12,2) and 8,94 (7,81–10,1) CU (all p < 0,05).

Conclusion. Compensation of PHT is accompanied by improvement of aortic elasticity and vasomotor endothelial function. There are no differences in aortic elasticity and vasomotor endothelial function in hypertensive and normotensive patients during decompensation and after euthyroid state achievement. 

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