Impact of dyslipidemia on early structural andgeometrical remodeling of the heart in hypertensivepatients

Abstract

Objective. To examine the contribution of dyslipidemia (DLP) in early left ventricular remodeling in patients with uncomplicated arterial hypertension (AH) of 1 degree. Design and methods. An open cross-sectional study of 378 patients with AH 1 degree was carried out using echocardiography and bifunctional 24-hour blood pressure and electrocardiography monitoring. Results. Using the standard echocardiography the influence of DLP on left ventricular was not found. Patients with AH and DLP showed a statistically significant increase of LV mass index (р < 0,01), relative wall thickness (р < 0,01), myocardial systolic stress (р < 0,01), end diastolic pressure (EDP; р < 0,01), end diastolic strain (EDS; р < 0,01), and diastolic remodeling index (р = 0,01). We found out that abnormal LV remodeling types were prevalent in patients with AH with DLP. The impact of DLP in cardiac remodeling was estimated by comparing groups AH and AH with DLP, and we found an increase of LV EDP (p < 0,01) and EDS (p < 0,01). Conclusion. Patients with AH 1 degree with DLP demonstrate early deterioration of LV diastolic function including increase of wall stiffness and LV EDP.