Combined antihypertensive therapy

Abstract

To assess effectiveness of the fixed combination of perindopril and amlodipine (Prestans, Servier, France) in hypertensive patients. Design and methods. We examined 12 patients with 2-3 stage of arterial hypertension, average age was 56,3 ± 11,8 years. Biochemical blood tests, «office» blood pressure (BP) by Korotkov method and 24-hour BP monitoring were performed initially and after 4 weeks of Prestans (1 pill per day) therapy. Conclusion. Prestans decreased «office» systolic BP, systolic BP time index and level of morning diastolic BP elevation. Fixed combination of perindopril and amlodipine was shown to be metabolically neutral.