Association of rs12204590 polymorphism with the development of stroke in hypertensive patients
S. Yu. Nikulina,
V. A. Shulman,
A. A. Chernova,
S. V. Prokopenko,
D. A. Nikulin,
I. M. Platunova,
S. S. Tretyakova,
A. A. Semenchukov,
O. V. Marilovtseva,
A. N. Kelemeneva,
V. N. Maksimov,
A. A. Gurazheva https://doi.org/10.18705/1607-419X-2019-25-5-549-556
Abstract
The stroke is one of the most serious complications of arterial hypertension (HTN). Genetic markers of the disease can be used to improve the risk stratification. According to the literature data of single nucleotide polymorphism (SNP) rs12204590 (T > A) is a new potential genetic marker for stroke, however, in published studies, cardiovascular pathology preceding stroke was not assessed.
Objective. To study the association of SNP rs12204590 (T > A) with the development of stroke in patients of the East Siberian population with HTN and without HTN. Design and methods. The study involved 260 patients with stroke (age 57,0 [51,0-62,0] years) and 272 patients of the control group (age 55,0 [51,0-62,0] years). Among stroke survivors, there were 157 men and 103 women. The control group included 170 men and 102 women. 249 patients ofthe main group and 177 patients of the control group had HTN. The following risk factors for the development of stroke were present in the main group: paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostasis system. All participants underwent clinical, instrumental and molecular genetic research. Statistical analysis was carried out using the programs Statistica for Windows 7.0, Excel and SPSS 22.
Results. The association of TA genotype SNP rs 122045 90 (T > A) with the development of stroke was confirmed in the main group, as well as in the subgroup of HTN patients who had stroke. An association of the AA genotype with stroke was found in males. Associations of the studied polymorphism with the risk factors for stroke were not identified.
Conclusions. The TA genotype rs12204590 (T > A) reduces the risk of acute stroke compared to the genotypes TT and AA, which is also observed in HTN patients. The AA SNP genotype rs12204590 (T > A) increases the risk of developing stroke in males.
Keywords
stroke,
hypertension,
rs12204590,
supraventricular tachycardia,
dyslipidemia,
atherosclerosis,
hemostasis
Supporting agencies: This work was supported by the grant of the President of the Russian Federation MD-58887.2018.7
About the Authors
S. Yu. Nikulina
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Svetlana Yu. Nikulina - MD, PhD, DSc, Professor, Acting Rector, Vice-Rector for Academic Affairs, Head, Department of Internal Diseases № 1
V. A. Shulman
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Vladimir A. Shulman - MD, PhD, DSc, Professor, Department of Internal Diseases № 1, Krasnoyarsk State Medical University n. a. professor V F. Voyno-Yasenetsky, Chairman
A. A. Chernova
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Anna A. Chernova - MD, PhD, DSc, Associate Professor, Department of Internal Diseases № 1, Senior Researcher, Russian-Italian Laboratory of Medical Genetics, Research Institute of Molecular Medicine and Pathobiochemistry, KrasSMU n. a. professor V. F. Voyno-Yasenetsky, Specialist of Functional Diagnostics, KrasICH № 20 n. a. I. S. Berzon
S. V. Prokopenko
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Semen V. Prokopenko - MD, PhD, DSc, Professor, Head, Department of Nervous Diseases with a Course of Medical Rehabilitation
D. A. Nikulin
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky; Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Dmitry A. Nikulin - MD, PhD, Assistant, Department of Nervous Diseases with a Course of Medical Rehabilitation, Krasnoyarsk State Medical University n. a. professor V. F. Voyno-Yasenetsky, General Practitioner
I. M. Platunova
Krasnoyarsk Interdistrict Clinical Hospital № 20 named after I.S. Berzona
Russian Federation
Russian Federation
Irina M. Platunova - MD, PhD, Neurologist
S. S. Tretyakova
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Svetlana S. Tretyakova - MD, PhD, Laboratory Assistant, Russian-Italian Laboratory of Medical Genetics, Scientific Research Institute of Molecular Medicine and Pathobiochemistry.
1 Partizan Zheleznyak street, Krasnoyarsk, 660022A. A. Semenchukov
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Aleksey A. Semenchukov - MD, Researcher, Research Institute of Molecular Medicine and Pathobiochemistry, Senior Lecturer, Department of Biological Chemistry with a Course of Medical, Pharmaceutical and Toxicological Chemistry
O. V. Marilovtseva
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Olga V Marilovtseva - MD, PhD, Laboratory Assistant, Russian-Italian Laboratory, Medical Genetics Scientific Research Institute of Molecular Medicine and Pathobiochemistry
A. N. Kelemeneva
Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Alina N. Kelemeneva - 4th-year Student, Medical Faculty
V. N. Maksimov
Scientific Research Institute of Therapy and Preventive Medicine of the Federal Research Center of Institute, Cytology and Genetics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vladimir N. Maksimov - MD, PhD, DSc, Professor, Head, Laboratory of Molecular Genetic Studies of Therapeutic Diseases, Scientific Research Institute of Therapy and Preventive Medicine
A. A. Gurazheva
Scientific Research Institute of Therapy and Preventive Medicine of the Federal Research Center of Institute, Cytology and Genetics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Anna A. Gurazheva - MD, Junior Researcher, Laboratory of Molecular Genetic Studies of Therapeutic Diseases, Scientific Research Institute of Therapy and Preventive Medicine
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Review
For citations:
Nikulina S.Yu., Shulman V.A., Chernova A.A., Prokopenko S.V., Nikulin D.A., Platunova I.M., Tretyakova S.S., Semenchukov A.A., Marilovtseva O.V., Kelemeneva A.N., Maksimov V.N., Gurazheva A.A. Association of rs12204590 polymorphism with the development of stroke in hypertensive patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2019;25(5):549-556. (In Russ.) https://doi.org/10.18705/1607-419X-2019-25-5-549-556
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