Association of the APOA5 rs662799 polymorphism with acute stroke in patients with cardiovascular disease

Objective. To investigate the associations of polymorphic variants rs662799 of the APOA5 gene with the development of acute cerebrovascular accident in patients with cardiovascular pathology. Design and methods. The main group of our study included 260 patients with acute cerebrovascular accident on the background of cardiovascular diseases and 272 volunteers without cardiovascular diseases (control group). The age range of patients with acute cerebrovascular accident was from 32 to 69 years [57,0 (51,0–62,0) years], and the age range of the control group was from 37 to 68 years [55,0 (51,0–62,0) years]. There were 157 men (age 56,5 (51,0–62,0 years) and 103 women (age 57,0 (51,0–62,0) years) in the main group. The control group included 170 men (age 55,0 (51,0–62,0) years) and 102 women (age 55,0 (51,0–62,0) years). All patients with acute cerebrovascular accident underwent the following examinations: collection of complaints and medical history, clinical examination, brain computed tomography, electrocardiography, echocardiography, and ultrasound doppler. The control group represents a population sample of residents of Novosibirsk who were examined as part of the international HAPIEE project in Novosibirsk. The results of the molecular genetic analysis were obtained from 254 patients in the main group and 272 patients in the control group. Statistical analysis was carried out using the SPSS v. 23. Results. The heterozygous AG genotype and the G allele of the APOA5 gene were more prevalent in the stroke cohort compared to control group. Among patients with acute cerebrovascular accident, a statistically significant decrease in the number of carriers of the common AA genotype and the A allele of the APOA5 gene was confirmed compared to the control group. Conclusion. The results of our study proved associations of single-nucleotide polymorphism rs662799 (A > G) with the development of acute cerebrovascular accident. The AG genotype and the G allele of the APOA5 gene showed significant associations with acute cerebrovascular accident in the main group of patients, in the subgroup of men and in the subgroup of patients with hypertension. 

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