The discovery of renin. Robert Tigerstedt and Per Bergman
https://doi.org/10.18705/1607-419X-2025-2502
EDN: GECFTQ
Abstract
The history of the discovery of renin in 1896 by Robert Tigerstedt and Per Bergman, the life and creative path of these scientists are described. In animal experiments, they demonstrated that injection of the renal extract to the animals results in a significant increase in blood pressure. Later, they defined the location of renin synthesis (the renal cortex), its physical and chemical characteristics (peptide), analyzed vasoconstriction effect and pharmacokinetics (velocity and duration of the effect).
Supporting agencies: The author thanks Ms. Raisa Verkander (Sweden) for her help in studying the archival data on the biography of the hero of this article, Per Bergman.
About the Author
V. N. Khirmanov
Nikiforov Russian Center of Emergency and Radiation Medicine (EMERCOM of Russia)
Russian Federation
Russian Federation
Vladimir N. Khirmanov - MD, PhD, DSc, Professor, Head, Cardiovascular Pathology Department, The Federal State Budgetary Institution “Nikiforov Russian Center of Emergency and Radiation Medicine” (EMERCOM of Russia).
4/2 Academician Lebedev str., St Petersburg, 194044
Phone: +7 (812) 702–63–47
References
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For citations:
Khirmanov V.N. The discovery of renin. Robert Tigerstedt and Per Bergman. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2025;31(2):175-181. (In Russ.) https://doi.org/10.18705/1607-419X-2025-2502. EDN: GECFTQ
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