Renin-angiotensin-aldosterone system gene polymorphism and arterial hypertension in children
https://doi.org/10.18705/1607-419X-2009-15-4-475-480
Abstract
Objective. To study the I/D polymorphism of angiotensin converting enzyme gene (ACE), the M235T polymorphism of the angiotensinogen gene (AGT) and the A1166C polymorphism of the angiotensin II type 1 receptor gene (AGTR1) in children with arterial hypertension (AH) and in controls. Design and methods. 84 children with the diagnosis of AH, 146 children with normal values of blood pressure and 198 children of population sample were included in the study. АН was defined as systolic/diastolic blood pressure measurements higher than 95 age-gender-height percentile of the adopted reference values. DNA was extracted from blood samples according to standard protocols and analyzed by the PLFP method. Results. The frequency of T235 allele of the AGT gene was significantly higher in hypertensive patients than in children with normal values of blood pressure. The frequency of TT genotype in hypertensive patients was significantly higher than in two control groups. The frequency of T235 allele and TT genotype were significantly higher in group of hypertensive girls compared with girls of two control groups and in hypertensive boys compared with normotensive boys. The distribution of ACE genotype and allele frequency did not differ significantly between patients with АН and control subjects. There were no significant differences in the frequency of CC genotype and C allele of AGTR1 gene in children with АН compared with control subjects. Conclusion. The further investigations of larger samples of children with AH, confirmed by ambulatory blood pressure monitoring, are required for definition of the role of M235T angiotensinogen gene polymorphism in the development AH in children.
About the Authors
S. V. Kuzmina
St Petersburg State Medical Academy of Postgraduate Studies
Russian Federation
St Petersburg
Russian Federation
St Petersburg
O. A. Mutafyan
St Petersburg State Medical Academy of Postgraduate Studies
Russian Federation
St Petersburg
Russian Federation
St Petersburg
V. I. Larionova
St Petersburg State Pediatric Medical Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
References
1. Брязгунов И.П. Первичная артериальная гипертензия у детей и подростков // Вопросы современной педиатрии. - 2003. - Т. 2. - С. 68-71.
2.
3. Кисляк О.А. Артериальная гипертензия в подростковом возрасте. - М: Миклош, 2007. - С. 29.
4.
5. Vasan R.S., Larson M.G., Leip E.P. et al. Impact of high-normal blood pressure on the risk of cardiovascular disease // N. Engl. J. Med. - 2001. - Vol. 345. - P. 1291-1297.
6.
7. Appel L.J., Brands M.W., Daniels S.R. et al. American Heart Association. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association // Hypertension. - 2006. - Vol. 2. - P. 296-308.
8.
9. Barbalić M., Skarić-Jurić T., Cambien F. et al. Gene polymorphisms of the rennin-angiotensin system and early development of hypertension // Am. J. Hypertens. - 2006. - Vol. 19. - P. 837-842.
10.
11. Jiang X., Sheng H., Li J. et al. Association between rennin-angiotensin system gene polymorphism and essential hypertension: a community-based study // J. Hum. Hypertens. - 2009. - Vol. 23. - P. 176-181.
12.
13. Petrovic D., Bidovec M., Peterlin B. Gene polymorphisms of the rennin-angiotensin-aldosterone system and essential arterial hypertension in childhood // Folia. Biol. (Krakow). - 2002. - Vol. 50. - P. 53-56.
14.
15. Papp F., Friedman A.L., Bereczki C. et al. Renin-angiotensin gene polymorphism in children with uremia and essential hypertension // Pediatr. Nephrol. - 2003. - Vol. 18. - P. 150-154.
16.
17. Porto P.I., Garcнa S.I., Dieuzeide G. et al. Renin-angiotensin-aldosterone system loci and multilocus interactions in young-onset essential hypertension // Clin. Exp. Hypertens. - 2003. - Vol. 25. - P. 117-130.
18.
19. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents // Pediatrics. - 2004. - Vol. 114 (2 suppl. 4th report). - P. 555-576.
20.
21. Blin N., Stafford D.W. A general method for isolation of high molecular weight DNA from eukaryotes // Nucleic Acid Res. - 1976. - Vol. 3. - P. 2303-2308.
22.
23. Ribichini F., Steffenino G., Dellavalle A. et al. Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme: a major risk factor and a marker of risk for coronary stent restenosis // Circulation. - 1998. - Vol. 97. - P. 147-154.
24.
25. Hingorani A., Brown M. A simple molecular assay for the C1166 variant of the angiotensin II type receptor gene // Biochem. Biophys. Res. Commun. - 1995. - Vol. 213. - P. 725-729.
26.
27. Morise T., Takeuchi Y., Takeda R. Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension // J. Intern. Med. - 1995. - Vol. 237. - № 2. - P. 175-180.
28.
29. Флетчер С., Вагнер Э. Клиническая эпидемиология. - М.: Медиа Сфера, 1998. - С. 264-267.
30.
31. Rotimi C., Puras A., Cooper R. et al. Polymorphisms of renin-angiotensin genes among Nigerians, Jamaicans, and African Americans // Hypertension. - 1996. - Vol. 27 (3 Pt 2). - P. 558-563.
32.
33. Agachan B., Isbir T., Yilmaz H. et al. Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients // Exp. Mol. Med. - 2003. - Vol. 35. - P. 545-549.
34.
35. Ramachandran V., Ismail P., Stanslas J. et al. Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects // J. Renin Angiotensin Aldosterone Syst. - 2008. - Vol. 9. - P. 208-214.
36.
37. Giner V., Corella D., Chaves F.J. et al. Renin-angiotensin system genetic polymorphisms and essential hypertension in the Spanish population // Med. Clin. (Barc). - 2001. - Vol. 117. - P. 525-529.
38.
39. Glavnik N., Petrovic D. M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians // Folia. Biol. (Praha). - 2007. - Vol. 53. - P. 69-70.
40.
41. Bautista L.E., Vargas C.I., Orуstegui M. et al. Population-based case-control study of rennin-angiotensin system genes polymorphisms and hypertension among Hispanics // Hypertens. Res. - 2008. - Vol. 31. - P. 401-408.
42.
43. Cai S.Y., Yu F., Shi Y.P. Association of angiotensinogen gene M235T variant with essential hypertension // Zhejiang Da Xue Xue Bao Yi Xue Ban. - 2004. - Vol. 33, № 2. - P. 151-154.
44.
45. Kataoka S., Hashimoto N., Kakihara T. et al. Analysis of Met235 to Thr variant of the angiotensinogen gene in relation to the blood pressure and family history of essential hypertension in Japanese children //Acta Paediatr. Jpn. - 1996. - Vol. 38, № 4. - P. 312-316.
46.
47. Jeunemaitre X., Soubrier F., Kotelevtsev Y.V. et al. Molecular basis of human hypertension: role of angiotensinogen // Cell. - 1992. - Vol. 71. - P. 169-180.
48.
49. Giner V., Poch E., Bragulat E. et al. Renin-angiotensin system genetic polymorphisms and salt sensitivity in essential hypertension // Hypertension. - 2000. - Vol. 35(1 Pt 2). - P. 512-517.
50.
51. Dzida G., Sobstyl J., Puzniak A. et al. Polymorphisms of angiotensin-converting enzyme and angiotensin II receptor type 1 genes in essential hypertension in a Polish population // Med. Sci. Monit. - 2001. - Vol. 7. - P. 1236-1241.
52.
53. Jiang Z., Zhao W., Yu F. et al. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension // Chin. Med. J. (Engl). - 2001. - Vol. 114, № 12. - P.1249-1251.
54.
55. Ono K., Mannami T., Baba S. et al. Lack of association between angiotensin II type 1 receptor gene polymorphism and essential hypertension in Japanese // Hypertens. Res. - 2003. - Vol. 26. - P. 131-134.
56.
57. Sugimoto K., Katsuya T., Ohkubo T. et al. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study // Hypertens. Res. - 2004. - Vol. 27. - P. 551-156.
58.
59. Lapierre A.V., Arce M.E., Lopez J.R. et al. Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in San Luis // Biocell. - 2006. - Vol. 30. - P. 447-455.
Review
For citations:
Kuzmina S.V., Mutafyan O.A., Larionova V.I. Renin-angiotensin-aldosterone system gene polymorphism and arterial hypertension in children. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2009;15(4):475-480. (In Russ.) https://doi.org/10.18705/1607-419X-2009-15-4-475-480
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