Electromechanical and hemodynamical disturbances associated with left bundle branch block in hypertensive patients with coronary artery disease

To assess electromechanical features of dyssynchrony associated with complete left bundle branch block in hypertensive patients with coronary artery disease. Design and methods. 1^st group included 38 subjects (16 males and 22 females, mean age - 53,0 ± 9,7 years) without cardiovascular diseases. 2^nd group consisted of 24 patients (19 males and 5 females, mean age - 58,8 ± 8,9 years) who survived through myocardial infarction or coronary bypass surgery in past. Dyssynchrony was assessed at atrioventricular (AV), interventricular (IV) and intraventricular (VV) levels. Results and conclusion. Subjects from the 1^st group showed lower volume of left ventricle (end-diastolic and end-systolic volumes), better contractility, and parameters of diastolic function (besides isovolumic relaxation time) did not differ between the groups. Dyssynchrony was comparable at AV and IV levels, but patients with verified coronary artery disease ahd significantly higher VV dyssynchrony (69,6 ± 18,9 vs. 59,7 ± 15,0 msec, р < 0,03). There was no correlation between QRS duration and dyssynchrony at any level. However, left ventricular hypertrophy correlated with dyssynchrony.

hypertension, coronary artery disease, left bundle branch block, dyssynchrony, echocardiography

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