To estimate if left ventricular (LV) diastolic dysfunction in sportsmen can be considered as the early sign of overtraining syndrome 28 sportsmen involved in dynamic sports were included in the study In this cohort all concomitant pathologic conditions that may serve as the basis for LV diastolic dysfunction were excluded Sportsmen were arranged in two groups group 1 -with normal LV diastolic function (n=20), group 2 - with LV diastolic dysfunction detected by complex analysis of cardiac hemodynamics, including assessment of the pulmonary vein flow pattern (n=8) Maximal oxygen consumption, peak cardiac output, peak stroke volume and peak stroke index levels were significantly higher in sportsmen of control group (p=0,008, <0,0001, <0,0001, <0,0001, respectively) Relative tachycardia at rest and in the recovery period, and increased rated systolic blood pressure in pulmonary artery were also observed in sportsmen with LV diastolic dysfunction (p=0,001 <0 0001, 0,004, respectively) It seems to be true that impaired LV diastolic function, estimated by pulsed wave Doppler echocardiography, represents the early sign of overtraining syndrome in sportsmen

During the examination of clmicaly healthy individuals of young age using the Minnesota Multiphasic Personality Inventory and psychogeometric test we established that part of these individuals, who has had inherited genetic risk factors, has also had inconsistent mtrapersonal tendencies and relatively high level of uneasiness, which brings up the necessity to include different methods of psychological correction into the primary preventative maintenance of cardiovascular deseases (p<0 001)

The study addresses relation between psychological features and daily blood pressure profile in hypertensive pregnant females. Psychological testing and 24-hour blood pressure monitoring were performed. Personal featured in different patterns of blood pressure daily profile are revealed. The data obtained indicate the need of philological testing for hypertension in pregnancy in order to optimize its treatment.

The study addresses changes of cerebral circulation during perindopril therapy of hypertension. 33 hypertensive patients were included (males - 15 (45,5%); females - 18 (54,5%). 20 patients (60,6%) received perindopril e 4 mg per day, 13 patients of control group were treated by alternative antihypertensive drugs. Neurology status, cerebral circulation (Sonomed, Spectodem, Russia) were evaluated at baseline and after 6 months of treatment. Results obtained demonstrated that perindopril can improve cerebral circulation independently of blood pressure reduction and has angioprotective effect. In conclusion perindopril seems to be effective treatment of hypertension in patients with impaired cerebral blood flow. Transcranial Doppler can be used as effective tool for monitoring of cerebral circulation in such cases.

Arterial hypertension is the important reason of the morbidity and mortality of the patients with chronic kidney disease. The aim of this study was to estimate the feature of the arterial hypertension, vasomotor form endothelial dysfunction and level of VCAM1 at patients with chronic kidney disease at groups with achievement and not achievement target arterial pressure. At the moment of the survey the target arterial pressure was achieved at 70 (1 group) and not achieved at 31 patients (2 group). During investigation it was applied the complex of biochemical, immune-enzyme and instrumental methods. The vasomotor form of endothelial dysfunction was detected at all of patients. The improvement of endothelium-dependent vasodilatation was defined at patients with achieved target arterial pressure. The VCAM1 concentration was elevated only at the patients 2 group. This group was differ from the 1 group with more high arterial pressure, left ventricular hypertrophy, atrium enlargement, complex intima-media enlargement, decrease glomerular filtration rate. It was made the conclusion that achievement target arterial pressure facilitate the correction of vasomotor form of endothelial dysfunction.

The paper presents the results of research in which 50 women with essential hypertension illness (arterial hypertension I-II degree) have taken part. 20 patients received long-acting metoprolol therapy (Egilok - retard, EGIS AO) in the dose of 25-100 mg, if necessary in a combination with hydrochlorothiazide 25 mg. In group of comparison (30 subjects) treatment with enalapril (5-10 mg/сут) or by a combination of enalapril and hydrochlorothiazide was administarted. It is shown, that monotherapy by metoprolol-retard allowed to reach a «target» levels of blood pressure in 89,5 % of women, in 10,5 % cases the combined therapy was required. At 12-week of treatment significant improvement of parameters of concentration of attention and anxiety decrease was observed.

This study is the first blind placebo-controlled trial of moxonidine for chronic migraine. The subjects with migraine without aura (n= 30), mean frequency attacks of 5,6 per 4 weeks, were randomy assigned to a three month trial of moxonidine (0,2-0,4 mg/ day) or an identical placebo. Patients kept daily headache records. Twenty-one of 30 included patients completed the study. Five patients stopped medication because of drowsiness and dry mouth with moxonidine. and four other non-related reasons (one on M, two on placebo). The mean frequency attacks was signifcantly decreased, from 5,2 per 4 weeks during placebo period to 3,1 attacs during M (Wile. P=0.0017), as well as compared with the baseline period (Wile. P=0.0007). Forty nine percent were responders (i.e. showed a reduction of the midraine days to 50 percent or less of the migraine attaks during M treatment compared with baseline period), whereas 9 percent deteriorated. During the placebo period, 9 percent were responders, whereas 38 percent deteriorated. These findings suggest that moxonidine may be an effective drug in chronic migraine.

Obstructive sleep apnea syndrome (OSA) is life-threatening condition in adults and children. Prevalence of OSA in adult and pediatric population is not well-established as not all patients have clear clinical picture. In Britain prevalence of OSA syndrome is comparable to asthma disease. Acetazolamide can cause metabolic acidosis, which can stimulate pulmonary ventilation and proposed to be effective in treatment of sleep breathing disturbances. Acetazolamide is widely used to therapeutic treatment of central OSA in adults and children. In adults administration of this drug can have problems of tolerance if administrated chronically. Alternatively, in children, OSA is usually transitory condition is early childhood what allow to treat it with acetazolamide effectively.

The study addresses cervical vertebral condition and myofascial pain syndrome as a contributor to arterial hypertension. 400 subjects working in a railways (locomotion brigades) of the Kuvbishev railway were examined. The effective system of prevention and combination therapy of hypertension with myofascial pain syndrome in introduced.