The aim of this investigation is the comparison of captopril and eprosartane influence on the level blood pressure, its variability and baroreceptor reflex in normal rats and rats with vasorenal hypertension.
It was shown that hypertensive rats had higher level of blood pressure, heart rate and its variability than normotensive rats. There was no relationship between arterial blood pressure and its variability in normal as well as hypertensive rats.
Captopril decreased blood pressure and had no effect on variability of blood pressure. In rats with renovascular hypertension an increased baroreflex and decreased variability of heart rate was note.
Eprosartan, as well as captopril, decreased blood pressure, but increased variability of blood pressure in rats with hypertension.

The paper presents the results of 24-weeks follow-up and treatment patients with metabolic syndrome.
It shows antihypertensive effect of imidazoline-receptor agonist moxonidine and hypolipidemic effect of micronized fenofibrate in patients with metabolic syndrome. The combination demonstrate synergic action on carbohydrate and uric acid metabolism. Thus, it can significantly decrease the level of cardio-vascular risk (SCORE) in patients with metabolic syndrome.

To study whether lymphocytes from patients with mild essential hypertension differ from healthy persons in the levels of mRNAs encoding Na/H exchanger (NHE1), some other ion transporters, i.e. sodium pump (ATP1B1), NaK2Cl symporter (NKCC1), and proteins unrelated to ion transport: glycolytic enzyme (GAPDH), antiapoptotic regulator (BC1-2) and kinase hSGK. Methods: Human peripheral blood lymphocyte mRNAs were assayed by RT PCR procedure. The amount of cDNA was quantified by photometry of electrophoretic bands stained with ethidium bromide, using digital photocamera and PC program. Hypertensive group included 26 males aged 18-30 years with mild essential hypertension, while normotensives -18 males with the same baseline characteristics except that for blood pressure. Results: The levels of NHE1, ATP1B1, NKCC1, GAPDH mRNAs, but not Bcl-2 or hSGK, in lymphocytes from hypertensives are higher than in normotensives by about factor 2.4-2.6 for ion transporters and 3.5 for GAPDH. Conclusions: The lymphocytes from young males with mild hypertension differ from normotensive ones in that there is a change in abundance of a group of mRNAs comprising not only NHE1, but either ATP1B1, NKCC1, and GAPDH mRNAs. The NHE1 effect is not specific.

The aim of the present study was to compare efficacy of bisoprolol and rilmenidine in patients with 1-2 stage hypertension and obstructive sleep apnea syndrome (OSA). In an open-label controlled randomized study 60 patients received rilmenidine 1-2 mg per day or bisoprolol 5-10 mg per day for 12 weeks. Ambulatory blood pressure monitoring (ABPM) and polysomnography was performed twice initially and at the end of the study. "Office" blood pressure (BP) and 24-hour BP decreased significantly in both groups. However, in rilmenidine group the normalization of diurnal BP index was more frequently observed as well as decrease of apnea index. The results obtained indicate that rilmenidine is equally effective with bisoprolol as antihypertensive medication, but additionally decrease nighttime BP possibly due to decrease of sympathetic overactivity. Revealed effect on parameters of OSA opens a new spheаre of rilmenidine administration in hypertension.

The study objective was to investigate serum concentrations of matrix metalloproteinase-9 (MMP-9) and it inhibitor (TIMP-1) in patients with aortic stenosis and mitral or aortic regurgitation. It was revealed that serum MMP-9 and TIMP-1 levels correlated with type of left ventricular hypertrophy. In patient with mitral or aortic regurgitation (volume load) MMP/TIMP ratio was increased due to prevalence of MMP-9. Increased serum ММР-9/TIMP-1 index was related to enlargement of left ventricular end-diastolic volume. The greatest disbalance in matrix metalloproteinase system was observed in patients with inherent connective tissue disease. In patients with pressure load hypertrophy (aortic stenosis) serum MMP blockade prevalence was observed, which promoted heart fibrosis development. Furthermore, increased serum TIMP-1 level was associated with decreased left ventricular injection fraction in patients with aortic stenosis.

The purpose: To estimate diastolic function left ventricle at persons of young age with recently revealed arterial hypertension and to reveal early attributes of its infringement.
Materials and methods: On device LOGIQ 500 method Doppler echocardiography studies diastolic function left ventricle at 34 patients of young age with prescription of revealing arterial hypertension no more than 3 years and practically healthy 48 persons.
Results: At an arterial hypertension already in a debut of revealing of disease change of some Doppler echocardiography parameters diastolic fillings left ventricle takes place: decrease in high-speed parameters early diastolic fillings and increase in peak speed and fraction of late filling left ventricle, that reflects difficulty of filling left ventricle and increased hemodinamic loading on the left auricle.
The conclusion: Changes of speeds diastolic fillings left ventricle reflects its structurally functional remodeling and can be used as criterion of diagnostics of defeat of heart at arterial hypertension

A study of daily blood pressure (BP) dynamics, functional endothelial condition at hypertensive patients in combination with tuberculosis of various localization and estimation of an opportunity of correction of the revealed disturbances during 12-week therapy by the fixed combination of perindopril and indapamide - noliprel-forte (Servier, France) were performed. During research more expressed endothelial dysfunction at hypertensive patients, proceeding on a background of tubercular process in comparison with patients with isolated arterial hypertension was revealed. Therapy by noliprel-forte provided the reliable 24-hour control of BP level, which was accompanied by endothelial function normalization that was shown by improvement of a endothelium-dependent vasodilatation and decrease of a von Willebrand factor level. .

Hypotensive drug tolerance and liver monooxygenase activity were investigated in 24 refractory arterial hypertension patients before and after surgical suppression of adrenal hyperfunction. Liver monooxygenase activity was studied using antipyrine test. It was found that hypotensive drug tolerance was decreased after one and two side operations on adrenal glands. In parallels halftime of antipyrine elimination was shown to be prolonged by 88.5% in 3 months - 3 years after suppression of adrenal hyperfunction. Our findings suggest that the hypotensive drug tolerance diminution may be the consequence of liver monooxygenase activity reduction. This assumption is in accordance with well known the hypotensive drug metabolism by microsomal liver monooxygenases

The issues of use of beta-blockers as first-line antihypertensive treatment and their negative metabolic effects are debated during last two years. At the same time beta-blockers are heterogeneous class of drugs, characteristics some of them may be different. At the article was presented the results of examination of 50 patients with hypertension 1-2 stage and high risk of cardiovascular complication which have confirmed the previous data that betaxolol is metabolic neutral, effective and good carried beta-blocker

Purpose: To compare vasomotor endothelial function in patients with coronary artery disease (CAD) with and without VA occurring during myocardial ischemia.
Methods: We studied 48 patients with CAD who had electrocardiographic signs of ischemia during ergometer exercise testing. All patients were divided into 2 equal groups: group I with VA occurred at peak exercise or during recovery and group II without VA. Exercise test duration was similar in the groups I and II. None of the patients had severe arterial hypertension, diabetes mellitus or signs of heart failure. Assessment of endothelial-dependent flow-mediated vasodilation (FMD) and endothelial-independent nitroglycerin-mediated vasodilation of brachial artery (BA) was performed using high-resolution ultrasound. Plasma endothelin-1 levels were measured by immunoassay method.
Results: FMD of BA was lower and duration of ischemic changes of ECG during recovery was greater in the group I compared with group II. There were no significant differences in plasma ET-1 levels among the groups I and II.
Conclusions: The patients with CAD and VA occurring during ischemia have FMD impaired to a greater degree and duration of ischemic changes of ECG in recovery longer compared with ones without VA.