In the submitted review value of increase of vascular resistance and a vascular tone in development of an isolated arterial hypertension has been shown. Parameters of elasticity of the arteries, used for the characteristic of properties of a vascular wall are discussed. In the review modern methods non invasive study of the properties of the arterial wall was described. The special attention has been given study of the pulse wave velocity, value of parameters of resistance and arterial stiffness for an estimation of the forecast was shown.

New data about the influence of thyrotoxicosis on the CVS, heart geometry, long-term cardiovascular prognosis and mortality, modern concept of pathogenesis of thyrotoxic miocardial remodeling, possibility of its reversal are described in present review. Also in this paper there are some data about the possibility of drug treatment of thyrotocic miocardial remodeling and its prevention.

Presented are the results of research of one of the main arteries rigidity index - pulse transit time (PTT) acquired at the processing of 24-hour monitoring data obtained by the portable recorder BPLab®. The work shows correlation of PTT index and BP in 24-hour dynamics. It demonstrates stable correlation of PTT value with other arteries rigidity indices taken by stationary equipment(VS-1000, Fukuda).

Objective: to study the evolution of ECG left ventricular hypertrophy (LVH) in patients with high risk arterial hypertension (AH) with during long-term antihypertensive treatment.
Design and methods. 102 patients (48% males, average age 67,1+0,6) with AH of high risk were randomized to antihypertensive therapy based on AT1 angiotensine II receptors anatagonists (ARA) or dihydropiridine calcium channel blockers (CCB). To achieve target blood pressure (BP) <140/90 mm Hg a diuretic and then other antihypertensive drugs could be added, besides CCB to ARA and ARA or ACE inhibitors to CCB. 12-leads ECG with assessment of ECG criteria of LVH was performed initially and in 1 year. LVH was diagnosed in case of presence of at least one of three criteria (Sokolow-Lyon Index>35 mV, Cornell voltage criteria>20 mV in females and > 28 mV in males and Cornell product >2442 msec*mV).
Results: In 1 year of treatment regress of LVH was observed in 8 from 31 (25,85%) patients with initially ECG- LVH. Patients with regress of ECG - LVH were younger and had lower BMI versus patients with of ECG-LVH persistence (65,5±2,4 vs 66,7±5,9 years and 28,6±5,6 vs 29,2±4,3 kg/m² respectively, n.s.); and significantly lower systolic BP (SBP) after 1 year treatment (137,8±7,6 mmHg vs 142,3±6,2 mmHg respectively). Step logistic regression analysis revealed that SBP was the only independent factor related with regress of ECG-LVH. baseline. Those patients were non significantly older (69,4±6,4 vs 66,0±6,2 years) and had higher blood glucose and total cholesterol levels both at baseline and after 1-year treatment and higher SBP after 1 treatment. Independent correlation with ECG-LVH development was found only for SBP, glucose and total cholesterol vlaues after 1-year treatment. There was no correlation between evolution of LVH and the type of treatmen.
Conclusion. Persistence and development of ECG-LVH in patients with high risk AH during long-term antihypertensive treatment is mainly associated with insufficient SBP control. Data on value of glucose and total cholesterol levels suggests potential benefit of treatment regimens with complex correction of risk factors for prevention of ECG-LVH development.

The aim of the research is to study remote (3 years) forecast of the patients with arterial hypertension (AH) with crisis current associated with type 2 diabetes and without diabetes, and to estimate the efficiency of the antihypertension therapy.
Comparison analysis of cardiovascular complications in 120 patients with AH with type 2 diabetes (n=60) and without diabetes (n=60) was carried out. Initially the groups were identical on AH duration and the current of cardiovascular complications, hi 3 years a higher frequency of cardiovascular complications in patients with AH with diabetes compared to the patients without diabetes was detected. Besides, the patients with chronic cardiac failure increased by 21,7%, with stenocardia by 20%, with myocardial infraction by 13,4%, with cerebral stroke by 11,7%, the mass of left ventricle myocardium has increased by 15%, lethality is 8,3%.
The showings of the patients with AH without diabetes were 11,7%, 15,0%, 6,7%, 6,7%, 5,9%, and 3,2% accordingly. A low efficacy of secondary drug prophylaxis of AH in the patients of both groups has been marked. Among the patients with AH and diabetes only 58,3% underwent a regular treatment, without diabetes - 31,7%. 41,7% and 68,3% patients underwent a treatment on an irregular basis. Target levels of AH were reached in 18,3% and 15,0% patients correspondingly.

The study addresses efficacy of fixed combinations of perindopril and indapamide (Noliprel and Noliprel-forte) in inadequately controlled hypertensive patients previously treated by free administrated combination therapy. 122 patients were followed-up for 3 months. Patients with mild hypertension were treated by Noliprel and patients with moderate-to-severe hypertension received Noliprel-forte. Efficacy, tolerability and quality of life were assessed initially and after 12 weeks of treatment. Is was shown that fixed combinations of perindopril and indapamide can help to effectively reach target blood pressure and can be successfully used as a "step" approach of therapy of different stages of hypertension.

The goal of this study was to see association between angeotensin-convertion enzyme (ACE) gene polymorphism, angeotensin II type 1 receptor (ATR₁), apoproteine E (APO E), apolipoprotein CIII (APO CIII), methylentetrahydrofolate reductase (MTHFR), fibrinogen (Fb), also endothelial NO-synthesis gene polymorphism (NOS3), and stroke frequency in patients suffering from AH (Arterial Hypertension) (n=41). Also to study the influence of these genes polymorphism on the characterizing parameters of AH (arterial hypertension).
Conducted study shown that stroke frequency in patients with AH (arterial hypertension) associated with A1166C ATR₁ gene polymorphism, G-455A Fb gene polymorphism and C677T MTHFR gene polymorphism. And at the same time high risk markers and C- allele of ATR₁ gene and AA genotype of Fb-gene, and protection part in stroke origin in AH (arterial hypertension) patients play A-allele and genotype AA of ATR₁ gene, CC genotype of MTHFRg gene. Also figured out that patients with I/D and DD-genotype of ATR-gene, AC and CC genotypes of ATR₁ gene, TT and CT genotypes of MTHFR gene, AA-genotype of Fb, authentically valuable meaning have parameters of functional condition of cardio-vascular system and metabolic status which determines risk degree of stroke in AH-patients.

The aim of the study was to investigate the influence of bradykinin type 2 receptor and angiotensinogen genes polymorphism on clinical features of hypertension and efficacy of the angiotensin II receptor blocker (Losartan) and ACE inhibitor (enalapril) in patients with mild-to-moderate hypertension. We examined 140 hypertensive patients; mean duration of hypertension constituted 9,3±2,7 years. Ambulatory blood pressure monitoring, ECHO-cardiography and genes polymorphism definition were done in all patients, with the repeated blood pressure monitoring used as a criteria of treatment efficacy. As a result it was determined, that blood pressure was higher in patients with T/T polymorphism of angiotensinogen gene and +9/+9 polymorphism of type 2 bradykinin receptor gene. Left ventricular mass index was higher in patients with M/M and +9/+9 polymorphisms, and the antihypertensive effect of the drugs was higher in patients with +9/+9 polymorphism.

Autonomic dysfunction is associated with negative prognosis in cardiovascular patiens and several other pathologies. Arterial baroreflex sensitivity is an important marker of autonomic regulation. Present work is devoted to the new approach to spontaneous baroreflex estimation, which permit to improve quality of the continious blood pressure and ECG monitoring analysis. The method of combined estimation of probability density of blood pressure and R-R intervals is proposed in this article, which improves efficacy of use of date records due to the increased number of included beats in calculation. This method is appeared to have better reproducibility and, probably, sensitivity for autonomic dysfunction diagnosis compared to traditional approaches. Moreover, offered method allow to measure additional arterial barorexlex characteristics. Thus, the calculation of barorexlex sensitivity combined probability density allows to wide the sphere of spontaneous baroreflex estimation, including changeable conditions.

In a multicenter uncontrolled titration study efficacy of carvedilol alone and in combination with amlodipine was studies in patients with hypertension and hypercholesterolemia. The study showed high efficacy of carvedilol as a monotherapy and combined with amlodipine in correction of hypertension and positive changes in lipid profile.