Vol 11, No 4 (2005)
REVIEWS
ORIGINAL ARTICLES
N. P. Dorofeev,
A. A. Kastanayan,
S. V. Shlyk,
V. V. Dorofeikov,
A. A. Barbina,
O. I. Nakhratskaya,
R. L. Kalmakov,
A. A. Dmitrieva,
R. V. Sidorov,
S. V. Grcbcnyuk,
A. A. Zubkova,
A. I. Kozarenko
235-238 935
Abstract
The purpose of the Study was to search for an association of the gene polymorphism of angiotensin-converting enzyme (ACE), angiotensinogen (ATG) and type I receptors of angiotensin II with the risk for chronic heart failure in patients with coronary heart disease (CHD) and arterial hypertension (AH). A hundred persons, including 80 patients with CHD, 10 patients with hypertensive disease, and 10 healthy Individuals were examined. There was no association of the ID gene polymorphism of ACE, MT gene polymorphism of ATG, and the AC gene polymorphism of ATR1 with the risk for heart failure in patients with CHD and AH.
249-251 1002
Abstract
The remodeling types of the left ventricle (LV) and their association with cardiac arrhythmias have been studied in patients with arterial hypertension. Atrial fibrillation predominates in patients with eccentric LV hypertrophy. The risk of atrial fibrillation increases by 1.8 times with the larger sizes of the left atrium Ventricular premature beats are common in patients with he concentric remodeling and concentric hypertrophy of the LV. The increased LV mass index leads to a 3-fold rise- in the risk of ventricular contract beats and to its 1-fold rise when the relative LV wall thickness becomes increased.
252-256 9522
Abstract
The purpose of the present study was to estimate the parameters of signal-averaged ECG in patients with hypertensive disease (III)) with different types of diurnal blood pressure (BP) variations. The study covered 127 patients aged 30 to 73 years (mean 53.4 ± 9.7 years) who Stages I-II HD. All the patients underwent estimation of late ventricular potentials (LVP) by recording signal-averaged ECG (SA-ECG) and 24-hour BP monitoring (24-h BPМ). The study did not reveal significant differences in the recording of LVP and in the parameters of SA-ECG in patients with HD with varying degrees of arterial hypertension. This was also confirmed by the fact that there were no significant differences in the parameters of 24-h BPM in the groups of hypertensive patients with and without LVP. In patients with BP, the impaired diurnal BP variations were ascertained to be associated with the increased detection rate of LVP. The most pronounced deterioration of SA-ECG parameters was observed in patients with an excessive nocturnal Ml' lowering the over-dipper type. In patients with HD, even an isolated excessive nocturnal diastolic BP lowering was shown to be followed by worse SA-ECG parameters. The findings are also supported by the correlations found between the parameters of SA-ECG and the values of 24-h BPM.
261-264 827
Abstract
The association of clinical and functional parameters was studied in patients with mild and moderate arterial hypertension (All) during therapy with betaxolol (Lokren), Twenty six patients (19 males and 7 females) aged 28 to 56 (mean 40.5 ± 1.4) years who had grade 1-2 AH were examined. The patients received monotherapy with betaxolol in a single dose of 10 mg/day. 24-hour ECG and blood pressure monitoring, stress-echocardiography during the arithmetic test estimating cognitive functions and life quality by the SP-36 scale were performed at the baseline and following 8 weeks of therapy. It has been found that betaxolol (Lokren) used In a single dose of 10 mg/day for 8 weeks has a high antihypertensive efficacy, stabilizes the autonomic balance of cardiac rhythm regulation, by simultaneously showing antiarrhythmic properties, reduces the degree of stress responsiveness, and enhances the inhibition of the central nervous system, by ultimately improving the quality of life in the patients.
265-270 998
Abstract
Objective. To study the specific features of cardiovascular responsiveness to acute alcoholic load in healthy male volunteers in relation to the genotype of alcohol dehydrogenase-2 (ADG2) by 24-hour monitoring of blood pressure (BP) and heart rate (HR) Methods. A study group comprised 32 healthy males (mean age 22.9 years) episodically consuming alcohol without a history of abnormal reactions, arterial hypertension (AH) and taking no antihypertensive agents, who had a level or clinical BP of < 140/<90 mm Hg. The alcohol load was 1.5 g of absolute ethanol per kg hotly weight. The BP measured at the same o'clock on the day of taking a soft drink was regarded as a control level. 24-hour monitoring was made on the day of using alcohol and a soft drink. The genotypes of ADG2 and aldehyde dehydrogenase 2 (AIDG2) were determined by polymerase chain reaction according to the standard protocol. Results. 20 (62.5 %) persons were carriers of the ADG2 - 1/1 genotype; the homozygotes of ADG2 - 2/2 were absent; all the participants had the ALDG2 - 1/1 genotype. The total group showed no differences in the average values of systolic (SBR), diastolic (DBP), mean (Bpmean), and pulse pressures (PP) on the day of taking vodka and a control soft drink during a day, daylight and night hours. The ADG2 - 1/1 group exhibited an insignificant increase in SBP and PP and a significant rise in HR on the day of taking vodka versus the control drink The persons with the AGD2 - 2/1 genotype responded to alcohol use as an insignificant decrease in BP and a less marked increase in HR during daylight hours and a more pronounced rise in HR at night. The same direction of differences in PP values was noted in the period of the maximum alcohol concentration in the expired air. In the period of alcohol elimination. MP and HR after alcohol use did not differ from these parameters after taking the soft drink, but the tendency for higher values in the ADG2 - l/l genotype group persisted, while in the ADG2 - 1/2 genotype group, the higher values of HR only remained. Conclusions. Differences were established in BP and HR reactions to the ingestion of alcohol in heal i by volunteers according to the genotype of ADG2. Elevated BP in persons with the ADG2 - 1/1 genotype suggests that alcohol-induced arterial hypertension may develop in the individuals with this genotype during chronic alcohol intoxication.
271-274 968
Abstract
Late outcomes were analyzed in 67 patients with pulmonary hypertension, who had undergone surgical correction of acquired mitral valvular diseases in the period sofs months to 11 years (mean 4.6 years). In the late postoperative period, there was no significant difference in the survival rates, in the incidence of high functional class heart failure, and the quality of life in patients with mitral valvular diseases in the presence of pulmonary hypertension and in a normal pulmonary pressure.
ИНФОРМАЦИЯ
ISSN 1607-419X (Print)
ISSN 2411-8524 (Online)
ISSN 2411-8524 (Online)